Reduced susceptibility to penicillin of viridans group streptococci in the oral cavity of patients with haematological disease

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
K WestlingC E Nord

Abstract

The occurrence of oral penicillin-resistant viridans group streptococci (VGS) was studied in 50 patients with either newly diagnosed acute leukaemia or autologous peripheral stem cell transplants. One patient was excluded because of Staphylococcus aureus growth in the stem cell harvest. VGS were isolated from the oral cavity of 48 of the remaining 49 patients. Of these 48 patients, 12 (25%) yielded VGS resistant (MIC > 2 mg/L) to penicillin. These 12 patients had a higher frequency of septicaemia (p 0.04) and more days of treatment with trimethoprim-sulphamethoxazole (p 0.04) than patients who harboured susceptible or intermediately resistant VGS (MIC 2 mg/L). There were no other statistically significant differences between the two groups. It is important to be aware of the high level of penicillin resistance in oral VGS in patients with haematological disease, and this parameter should be considered when selecting antibiotic therapy for cases of septicaemia caused by VGS in immunocompromised patients.

References

Dec 1, 1977·Journal of Pharmacokinetics and Biopharmaceutics·F B EatmanS A Kaplan
Jul 1, 1990·The Journal of Antimicrobial Chemotherapy·L J Chalkley, H J Koornhof
May 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J CarrataláF Gudiol
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Y BochudP Francioli
Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M CrucianiE Concia
Feb 2, 1999·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·K G KerrP H McWhinney
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Andrea S GershonUNKNOWN Canadian Bacterial Surveillance Network
May 17, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R Tunkel, Kent A Sepkowitz

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Citations

Mar 13, 2013·Antimicrobial Agents and Chemotherapy·Cristina García-de-la-MàriaUNKNOWN Hospital Clinic Experimental Endocarditis Study Group
Aug 29, 2006·Seminars in Pediatric Infectious Diseases·Lauren Bruckner, Francis Gigliotti

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