PMID: 11909683Mar 23, 2002Paper

Reduced susceptibility to peroxidation of erythrocyte plasma membranes from centenarians

Experimental Gerontology
R A RabiniL Mazzanti

Abstract

The plasma membrane composition affects intracellular processes and the cellular susceptibility to free radical attack, which has been associated with the impairment of cellular functions occurring during senescence. The study of the modifications of the plasma membrane in centenarians might elucidate the biological mechanisms at the basis of longevity and successful aging. The work was performed in 190 subjects, divided into five groups according to the age range: (1) 21-40 years (n=25); (2) 41-60 years (n=30); (3) 61-80 years (n=30); (4) 81-99 years (n=50); and (5) centenarians (> or = 100 years) (n=55). The following determinations were performed on erythrocyte membranes: (i) the lipid peroxide level (Lp) evaluated as malondialdehyde content; (ii) susceptibility to in vitro oxidation evaluated as difference in the content of thiobarbituric acid-reactive substances before and after phenylhydrazine addition; (iii) unsaturated/saturated fatty acid ratio and individual polyunsaturated fatty acid composition measured by gas chromatography; and (iv) fluidity studied by means of the anisotropy of the probe 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH). Erythrocyte membranes from centenarians showed: (i) decreased b...Continue Reading

References

Apr 1, 1986·The American Journal of Medicine·D Zakim
May 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·K MinakataN Harada
Mar 19, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M LillingtonH L Makin
Jan 1, 1994·Methods in Enzymology·G van Ginkel, A Sevanian
Jan 1, 1993·Free Radical Research Communications·J M Gutteridge
Apr 2, 1998·BioFactors·S UranoT Endo
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
Jun 26, 1998·Clinical Science·E García-ArumíS Schwartz
Jul 22, 1998·Journal of the American Geriatrics Society·G PaolissoM Varricchio
Apr 10, 1999·Experimental Gerontology·P CaprariV Marigliano
Mar 25, 2000·Journal of the American Geriatrics Society·L MazzantiC Franceschi
Feb 24, 2001·Atherosclerosis·B MutusL Mazzanti

❮ Previous
Next ❯

Citations

Jun 7, 2005·Experimental Gerontology·Laura NanettiMazzanti Laura
Oct 3, 2012·Antioxidants & Redox Signaling·Kaitlyn N LewisRochelle Buffenstein
Dec 28, 2007·Rejuvenation Research·Annibale A PucaCarla Ferreri
Oct 19, 2012·Annals of Biomedical Engineering·Dangheng WeiGuixue Wang
Jun 15, 2012·Archives of Gynecology and Obstetrics·Rahime Bedir FindikJale Karakaya
Nov 24, 2012·Fertility and Sterility·Eleonora SalvoliniGiancarlo Balercia
Jul 31, 2007·Respiratory Physiology & Neurobiology·Claus BehnGustavo González
Aug 8, 2007·Mechanisms of Ageing and Development·Nilson Penha-SilvaRita de Cássia Mascarenhas Netto
May 17, 2005·Mechanisms of Ageing and Development·Byung Pal Yu
Apr 1, 2005·Journal of the American Dietetic Association·Marie Fanelli KuczmarskiUNKNOWN American Dietetic Association
Aug 13, 2008·Expert Opinion on Biological Therapy·E CeveniniC Franceschi
Jan 1, 2010·Current Gerontology and Geriatrics Research·Makoto SuzukiBradley J Willcox
Nov 9, 2006·Free Radical Research·S SalvioliC Franceschi
Oct 12, 2007·Physiological Reviews·A J HulbertW A Buttemer
Sep 25, 2019·Free Radical Biology & Medicine·Ángel Belenguer-VareaMarta Inglés
Apr 11, 2021·Biogerontology·I AlmeidaA Nunes
Apr 24, 2021·Developmental Cell·Ayse Sena MutluMeng C Wang
Nov 9, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Francesca Di CesareEdoardo Saccenti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.