PMID: 8610132Apr 2, 1996Paper

Reduced sympathetic innervation after alteration of target cell neurotransmitter phenotype in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America
S ChoT H Joh

Abstract

Neurotransmitters play a variety of important roles during nervous system development. In the present study, we hypothesized that neurotransmitter phenotype of both projecting and target cells is an important factor for the final synaptic linkage and its specificity. To test this hypothesis, we used transgenic techniques to convert serotonin/melatonin-producing cells of the pineal gland into cells that also produce dopamine and investigated the innervation of the phenotypically altered target cells. This phenotypic alteration markedly reduced the noradrenergic innervation originating from the superior cervical ganglia. Although the mechanism by which the reduction occurs is presently unknown, quantitative enzyme-linked immunoassay showed the presence of the equivalent amounts of nerve growth factor (NGF) in the control and transgenic pineal glands, suggesting that it occurred in a NGF-independent manner. The results suggest that target neurotransmitter phenotype influences the formation of afferent connections during development.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Jul 10, 1992·Brain Research·J E García-MauriñoJ L Calvo
Feb 1, 1991·Journal of Neurochemistry·M L FiszmanU di Porzio
Aug 25, 1987·Nucleic Acids Research·K KobayashiT Nagatsu
Jun 10, 1988·Science·R Jaenisch
Sep 4, 1987·Science·R Levi-Montalcini
Jan 1, 1986·Annual Review of Genetics·R D Palmiter, R L Brinster
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Korsching, H Thoenen
Jan 1, 1984·Journal of Pineal Research·P GovitrapongM Ebadi
May 19, 1995·Cell·J Dodd, A Schuchardt
Aug 15, 1994·Neuroscience Letters·G HernándezR Alonso
Jun 10, 1994·Science·B A Habecker, S C Landis
May 1, 1993·Neuron·E Frank, P Wenner

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Citations

Mar 3, 1998·Progress in Neurobiology·T Cowen, I Gavazzi
Mar 15, 2000·Reviews in the Neurosciences·M Bader

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