Reduced testosterone levels in males with lone atrial fibrillation.

Clinical Cardiology
Jiangtao LaiJianhua Zhu

Abstract

Sex hormones play an important role in the development of cardiovascular disease. Testosterone and estradiol have been reported to be down-regulated in subjects with coronary artery disease and heart failure, but has not been studied in atrial fibrillation (AF). Levels of sex hormones may be associated with susceptibility to lone AF in men. Fifty-eight male subjects who had electrocardiographic evidence of paroxysmal or chronic AF and a structurally normal heart on echocardiography were enrolled. Subjects were excluded if they had been taking angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or statins within 3 mo or had a history of coronary artery disease, rheumatic heart disease, cardiomyopathy, significant valvular disease, hyperthyroidism, or hypertension. Fifty-eight controls were recruited from a healthy outpatient population. Serum total testosterone and estradiol levels were determined using a commercially available radioimmunoassay. Mean levels of testosterone were significantly lower in subjects with lone AF when compared with controls (476 ng/dl versus 514 ng/dl, p = 0.005). No significant differences were found in the estradiol levels between the 2 groups (31.9 pg/ml versus 32.4 ...Continue Reading

References

Mar 1, 1987·Journal of the American College of Cardiology·D RoyM Cantin
Jan 1, 1993·Life Sciences·Y Deng, S Kaufman
Apr 16, 1998·QJM : Monthly Journal of the Association of Physicians·K M EnglishK S Channer
Apr 12, 2000·Journal of the American College of Cardiology·A RossiJ B Seward
Oct 13, 2000·QJM : Monthly Journal of the Association of Physicians·P J PughK S Channer
Feb 24, 2001·Journal of the American College of Cardiology·S S ChughB J Gersh
Jul 27, 2001·Journal of Cardiovascular Electrophysiology·B J BrundelR H Henning
Jun 6, 2003·Endocrine Reviews·Peter Y LiuDavid J Handelsman
Oct 30, 2003·The American Journal of Cardiology·Helme SilvetShmuel Ravid
Dec 6, 2003·The Journal of Pharmacology and Experimental Therapeutics·Raghvendra K DubeyEdwin K Jackson
Dec 17, 2003·The American Journal of Cardiology·Jens FribergGorm B Jensen
Jan 5, 2005·Journal of the American College of Cardiology·Patrick T EllinorCalum A Macrae
May 20, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Richard D JonesKevin S Channer
Jan 24, 2007·International Journal of Cardiology·Omer GedikliGurkan Acar

❮ Previous
Next ❯

Citations

May 20, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Li YangYin Dechun
Mar 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Gustavo F GonzalesCynthia Gonzales-Castañeda
Nov 15, 2011·European Journal of Internal Medicine·Xiaorong HuHong Jiang
Mar 11, 2010·International Journal of Cardiology·Tong LiuXunzhang Wang
Apr 20, 2018·Clinical Cardiology·Michael A RosenbergKenneth J Mukamal
Mar 13, 2014·Circulation. Arrhythmia and Electrophysiology·Jared W MagnaniAndrea D Coviello
Nov 27, 2009·Current Opinion in Cardiology·Abel Rivero, Anne B Curtis
Oct 24, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Katja E OdeningHikmet Yorgun
Apr 17, 2019·Expert Review of Cardiovascular Therapy·Rachel WamboldtAdrian Baranchuk
May 5, 2011·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Elie J ChahlaJohn E Morley
Dec 11, 2019·Journal of Cardiovascular Translational Research·Margarida LorigoElisa Cairrao
May 1, 2018·The World Journal of Men's Health·Jonathan Clavell-Hernández, Run Wang
Feb 19, 2021·Food Science & Nutrition·Limei ChenHuanhuan Dong
Aug 28, 2021·International Journal of Molecular Sciences·Ya-Ting ChangHong-Yo Kang
Apr 27, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.