PMID: 9416381Jan 7, 1998Paper

Reduced tetracycline bioavailability caused by magnesium aluminum silicate in liquid formulations of bismuth subsalicylate

The Annals of Pharmacotherapy
D P HealyG S Deepe

Abstract

Bismuth subsalicylate, tetracycline hydrochloride, and metronidazole are widely used in combination for the treatment of Helicobacter pylori infections. As a result, there is renewed interest in the interaction between tetracycline and bismuth subsalicylate. To determine whether the observed decrease in tetracycline bioavailability is due to the active drug bismuth subsalicylate via complexation, or to magnesium aluminum silicate (Veegum), an inactive excipient present only in the liquid formulation of bismuth subsalicylate, which might adsorb the tetracycline, rendering it unavailable for systemic absorption. Eleven healthy volunteers participated in a randomized three-period, three-treatment complete crossover study with a 7-day washout interval between treatments. After an overnight fast, subjects received a 500-mg capsule of tetracycline hydrochloride with either tap water, 30 mL of bismuth subsalicylate (525 mg) liquid containing Veegum (Pepto-Bismol), or 30 mL of a specially formulated bismuth subsalicylate (525 mg) liquid without Veegum. Blood was collected for 24 hours after each dose of tetracycline. Serum was assayed for tetracycline concentration by HPLC. In addition, standard in vitro ultraviolet spectrophotometric ...Continue Reading

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Jun 22, 2000·International Journal of Health Services : Planning, Administration, Evaluation·U Lövdahl, E Riska
Feb 24, 2010·Psychological Research·Bradley R Sturz, Kent D Bodily
Sep 16, 2010·Child Development·Sandra L Hofferth
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May 23, 2012·Pharmaceutical Research·Ravikiran Panakanti, Ajit S Narang
Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Ajit S NarangSherif Badawy
Sep 29, 2011·Drugs·Ryuichi Ogawa, Hirotoshi Echizen
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charles D Ericsson

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