PMID: 9420744Nov 1, 1994Paper

Reduced variability of interpretation and improved image quality with a technetium 99m myocardial perfusion agent: comparison of thallium 201 and technetium 99m-labeled tetrofosmin

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
R C HendelB L Zaret

Abstract

The purpose of this study was to determine the relative image quality and interobserver variability among four readers for 201Tl and 99mTc-labeled tetrofosmin myocardial perfusion images. 99mTc-labeled perfusion agents, with near-optimal physical characteristics for gamma camera imaging, may allow for superior image quality and improved consistency of interpretation. However, most studies to date have demonstrated only similarity in the diagnostic accuracy between technetium agents and thallium. Tetrofosmin is a recently developed 99mTc-labeled agent that has shown promising results in early clinical trials. A multicenter, open-label trial was performed during which treadmill exercise thallium and tetrofosmin scintigraphy was performed within a 2-week period of each other in 216 subjects. Image quality was evaluated subjectively and scans were interpreted in a blinded, independent fashion by four readers. Perfusion abnormalities were graded as consistent with ischemia, infarction, or mixed and were described both globally and regionally. Interobserver variability was assessed by use of the kappa statistic, and receiver-operator curves were compared for each observer for the diagnostic accuracy of each agent. More tetrofosmin im...Continue Reading

Citations

Mar 1, 1997·European Journal of Nuclear Medicine·R M AignerG Wolf
Dec 17, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Assuero GiorgettiPaolo Marzullo
Dec 14, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Allan JohansenTorben Haghfelt
Dec 14, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Abdou ElhendyDon Poldermans
Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ami E IskandrianTracy Faber
Dec 18, 2001·International Journal of Cardiology·J Ali RazaA Movahed
Sep 29, 1999·International Journal of Cardiology·A PasquetT H Marwick
Dec 12, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Abdou ElhendyDon Poldermans
Jul 1, 1997·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R S KhattarA Lahiri
Jun 29, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R J GolubG V Heller
May 9, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Reza ArsanjaniPiotr Slomka
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michel DahanFrançoise E Mignon
Jan 5, 2002·British Medical Bulletin·C AnagnostopoulosS R Underwood

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