Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease

Inflammatory Bowel Diseases
Zhouqiao WuJohan F Lange

Abstract

Anastomotic leakage after gastrointestinal surgery remains a challenging clinical problem. This study aimed to investigate the effectiveness of TissuCol (fibrin glue), Histoacryl Flex (n-butyl-2-cyanoacrylate), and Duraseal (polyethylene glycol) on colorectal anastomotic healing during experimental colitis. We first performed colectomy 7 days after 10 mg trinitrobenzene sulfonic acid (TNBS)-induced colitis to validate a rat TNBS-colitis-colectomy model. Subsequently, this TNBS-colitis-colectomy model was used in 73 Wistar rats that were stratified into a colitis group (CG, no adhesive), a TissuCol group (TG), a Histoacryl group (HG), and a Duraseal group (DG). Anastomotic sealant was applied with one adhesive after constructing an end-to-end hand-sewn anastomosis. Clinical manifestations, anastomotic bursting pressure, and immunohistochemistry of macrophage type-one (M1) and type-two (M2) was performed on postoperative day (POD)3 or POD7. TNBS-caused mucosal and submucosal colon damage and compromised anastomotic healing (i.e., abscess formation and low anastomotic bursting pressure). On POD3, higher severity of abscesses was seen in CG. Average anastomotic bursting pressure was 53.2 ± 35.5 mm Hg in CG, which was significantly ...Continue Reading

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Citations

Aug 12, 2015·International Journal of Colorectal Disease·Dominik S SchoebMarcel Binnebösel
May 19, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Luigi Marano, Natale Di Martino
Dec 3, 2016·Journal of Biomaterials Science. Polymer Edition·Youming DengJieshou Li
Jan 27, 2017·Biomacromolecules·Richard D O'RorkeTerry W J Steele
Sep 14, 2016·World Journal of Gastroenterology : WJG·Cloë L SparreboomJohan F Lange
Nov 21, 2018·American Journal of Veterinary Research·Liliana M MutascioMicha C Simons
Apr 3, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Seyede Sara SeyedizadeAmir Hossein Abdolghaffari

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