Reducing drug prescription errors and adverse drug events by application of a probabilistic, machine-learning based clinical decision support system in an inpatient setting.

Journal of the American Medical Informatics Association : JAMIA
G SegalE Zimlichman

Abstract

Drug prescription errors are made, worldwide, on a daily basis, resulting in a high burden of morbidity and mortality. Existing rule-based systems for prevention of such errors are unsuccessful and associated with substantial burden of false alerts. In this prospective study, we evaluated the accuracy, validity, and clinical usefulness of medication error alerts generated by a novel system using outlier detection screening algorithms, used on top of a legacy standard system, in a real-life inpatient setting. We integrated a novel outlier system into an existing electronic medical record system, in a single medical ward in a tertiary medical center. The system monitored all drug prescriptions written during 16 months. The department's staff assessed all alerts for accuracy, clinical validity, and usefulness. We recorded all physician's real-time responses to alerts generated. The alert burden generated by the system was low, with alerts generated for 0.4% of all medication orders. Sixty percent of the alerts were flagged after the medication was already dispensed following changes in patients' status which necessitated medication changes (eg, changes in vital signs). Eighty-five percent of the alerts were confirmed clinically va...Continue Reading

References

Mar 21, 2000·Texas Medicine·J Rohack
Apr 26, 2008·Journal of the American Medical Informatics Association : JAMIA·Heleen van der SijsArnold Vulto
Jul 15, 2009·British Journal of Clinical Pharmacology·Giampaolo P Velo, Pietro Minuz
Apr 7, 2010·Health Affairs·Jane MetzgerDavid C Classen
Sep 8, 2010·Health Affairs·Michelle M MelloDavid M Studdert
Jun 16, 2011·JAMA : the Journal of the American Medical Association·Tara F BishopLawrence P Casalino
Jul 19, 2013·Journal of Patient Safety·John T James
Jul 31, 2013·Joint Commission Journal on Quality and Patient Safety·Eyal ZimlichmanDavid W Bates
Oct 9, 2013·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Alexander A LeungDavid W Bates
Oct 10, 2014·Applied Clinical Informatics·A D BryantT H Payne
Oct 19, 2014·Journal of Medical Systems·Salvador Rodriguez LoyaVojtech Huser
Jan 21, 2017·Journal of the American Medical Informatics Association : JAMIA·Gordon D SchiffRonen Rozenblum
Oct 17, 2017·International Journal of Medical Informatics·Yael Zenziper StraichmanRonen Loebstein
Feb 14, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Clare L TolleyDavid W Bates

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Citations

Sep 29, 2020·Journal of the American Medical Informatics Association : JAMIA·Jennifer CornyAnne Buronfosse
Jul 25, 2020·JMIR Medical Informatics·Avishek Choudhury, Onur Asan
Oct 30, 2020·Journal of the American Medical Informatics Association : JAMIA·Ilona LeviatanGideon Y Stein
Dec 2, 2019·Joint Commission Journal on Quality and Patient Safety·Ronen RozenblumEnrique Seoane-Vazquez
Apr 23, 2021·Journal of Medical Internet Research·Jiamin YinHock Hai Teo
May 7, 2021·Journal of the American Medical Informatics Association : JAMIA·Sophie-Camille HogueMaxime Thibault
Nov 13, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Seunghee LeeSuehyun Lee

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