Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance

Pharmacology, Biochemistry, and Behavior
Amanda L McCallumL A Parker

Abstract

The potential of the fatty acid amide hydrolase (FAAH) inhibitor, URB597, to modify drug prime-induced reinstatement of morphine-induced conditioned floor preference or naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance was evaluated. In Experiment 1, morphine-induced conditioned floor preference was established across 4 conditioning trials. Following extinction training (4 trials), rats were pretreated with URB597 or vehicle prior to a morphine prime or a saline prime. Morphine reinstated the previously extinguished floor preference, but URB597 did not modify the strength of the reinstated preference. In Experiment 2, naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance was established across 2 conditioning trials. Following extinction training (14 trials), rats were pretreated with URB597 or vehicle prior to a saline prime or a morphine withdrawal prime. The morphine withdrawal prime reinstated the previously extinguished floor avoidance, but URB597 did not modify the strength of reinstated avoidance. These results suggest that under the conditions in which URB597 promotes extinction (e.g., Manwell et al. (2009)) it does not interfere with drug-induced reinstatement of eithe...Continue Reading

References

Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·L A Parker, R V Mcdonald
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·S A Varvel, Aron H Lichtman
Dec 4, 2002·Nature Medicine·Satish KathuriaDaniele Piomelli
Jan 8, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jasmeer P ChhatwalKerry J Ressler
Mar 3, 2005·European Journal of Pharmacology·Sabine M HölterCarsten T Wotjak
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·G GobbiD Piomelli
Jul 26, 2007·The European Journal of Neuroscience·Andrea CippitelliFernando Rodríguez de Fonseca
Oct 24, 2007·Molecular Neurobiology·Beat Lutz

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Citations

Apr 1, 2011·Expert Opinion on Drug Discovery·Radu TanasescuCris S Constantinescu
Jul 28, 2018·Acta Pharmacologica Sinica·Maria SchermaGianluigi Tanda

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