Reducing expression of GluN1(0XX) subunit splice variants of the NMDA receptor interferes with spatial reference memory.

Behavioural Brain Research
Siba Ranjan DasK R Magnusson

Abstract

The GluN1 subunit of the N-methyl-D-aspartate (NMDA) receptor shows age-related changes in its expression pattern, some of which correlate with spatial memory performance in mice. Aged C57BL/6 mice show an age-related increase in mRNA expression of GluN1 subunit splice variants that lack the N terminal splice cassette, GluN1(0XX) (GluN1-a). This increase in expression is associated with good performance in reference and working memory tasks. The present study was undertaken to determine if GluN1(0XX) splice variants are required for good performance in reference memory tasks in young mice. Mice were bilaterally injected with either siRNA specific for GluN1(0XX) splice variants, control siRNA or vehicle alone into ventro-lateral orbital cortices. A fourth group of mice did not receive any injections. Starting five days post-injection, mice were tested for their performance in spatial reference memory, associative memory and cognitive flexibility tasks over four days in the Morris water maze. There was a 10-19% reduction in mRNA expression for GluN1(0XX) splice variants within the ventro-lateral orbital cortices in mice following GluN1(0XX) siRNA treatment. Declines in performance within the first half of reference memory testing...Continue Reading

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Citations

Jul 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel R ZamzowKathy R Magnusson
Jan 15, 2013·Future Neurology·Kathy R Magnusson
Feb 4, 2016·Acta Biochimica Et Biophysica Sinica·Peijun Ju, Donghong Cui

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