Reducing healthcare-associated infections incidence by a probiotic-based sanitation system: A multicentre, prospective, intervention study

PloS One
Elisabetta CaselliSAN-ICA Study Group

Abstract

Healthcare Associated Infections (HAI) are a global concern, further threatened by the increasing drug resistance of HAI-associated pathogens. On the other hand, persistent contamination of hospital surfaces contributes to HAI transmission, and it is not efficiently controlled by conventional cleaning, which does not prevent recontamination, has a high environmental impact and can favour selection of drug-resistant microbial strains. In the search for effective approaches, an eco-sustainable probiotic-based cleaning system (Probiotic Cleaning Hygiene System, PCHS) was recently shown to stably abate surface pathogens, without selecting antibiotic-resistant species. The aim of this study was to determine whether PCHS application could impact on HAI incidence. A multicentre, pre-post interventional study was performed for 18 months in the Internal Medicine wards of six Italian public hospitals (January 1st 2016-June 30th 2017). The intervention consisted of the substitution of conventional sanitation with PCHS, maintaining unaltered any other procedure influencing HAI control. HAI incidence in the pre and post-intervention period was the main outcome measure. Surface bioburden was also analyzed in parallel. Globally, 11,842 patien...Continue Reading

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Citations

Aug 31, 2019·Drugs·Claudia Vuotto, Gianfranco Donelli
Apr 3, 2019·International Journal of Molecular Sciences·Maria D'AccoltiElisabetta Caselli
Jan 31, 2021·Microorganisms·Maria D'AccoltiElisabetta Caselli
Jan 1, 2019·Current Pollution Reports·Brent StephensJack A Gilbert
Jul 27, 2021·Oral Diseases·Pablo Alejandro Millones-Gómez

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

ISRCTN58986947

Software Mentioned

SPSS20®

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