Reducing infarct size in the setting of acute myocardial infarction

Progress in Cardiovascular Diseases
James M Downey, M V Cohen

Abstract

Acute myocardial infarction is caused by coronary occlusion, and the mainstay of treatment has become reperfusion by either coronary angioplasty with possible stenting or surgical bypass grafting. Unfortunately, reperfusion can seldom be done soon enough to prevent infarction. Thus, the search for effective cardioprotection has been ongoing for more than 3 decades. After establishment of a suitable animal model to test the efficacy of pharmacological agents and other interventions, investigators found ischemic preconditioning to be a powerful and reproducible cardioprotectant. Much of the signaling pathway from cell receptor to end-effector has now been established even if the identity of the latter has not been proven. Remarkably, the actual protection is believed to occur during reperfusion rather than during ischemia. Yet, the clinical applicability of ischemic preconditioning is limited because of the obligate need to initiate it before ischemia. However, several strategies have been developed that can be applied at the time of reperfusion and which, therefore, hold clinical promise. These interventions are thought to trigger the same signaling cascades as ischemic preconditioning, which include activation of extracellular ...Continue Reading

References

Dec 1, 1989·Journal of Molecular and Cellular Cardiology·K A ReimerV J Richard
Jun 28, 1969·Lancet·D Sodi-PallaresG A Medrano
Aug 1, 1973·Journal of Molecular and Cellular Cardiology·D J HearseE B Chain
Jul 16, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Qing ZhaoJakob Vinten-Johansen
Sep 25, 2003·Physiological Reviews·Derek M Yellon, James M Downey
Nov 26, 2003·Journal of Cardiovascular Pharmacology·Shi Jun ZhangJames M Downey
Sep 1, 2004·Journal of the American College of Cardiology·Xi-Ming YangMichael V Cohen
Jun 14, 2005·Cardiovascular Research·Hajime KinJakob Vinten-Johansen
Mar 21, 2006·Cardiovascular Research·Sebastian PhilippMichael V Cohen

❮ Previous
Next ❯

Citations

Mar 26, 2013·Pflügers Archiv : European journal of physiology·Donna H Korzick, Timothy S Lancaster
Jul 10, 2009·Annals of Biomedical Engineering·Sharon BarzelaiMickey Scheinowitz
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nathan D BozeatDayue Darrel Duan
Feb 28, 2007·BMC Cardiovascular Disorders·Goran K OlivecronaDavid Erlinge
May 15, 2010·International Journal of Occupational and Environmental Health·Angela Maria Pinzon-RondonMariano Kanamori
Apr 30, 2014·Revista Española De Cardiología·David Garcia-DoradoJavier Inserte
Nov 26, 2015·Archivos de cardiología de México·Amparo HernándizPilar Sepúlveda
Jul 17, 2007·Biochimica Et Biophysica Acta·Andrew P HalestrapIgor Khaliulin
Sep 30, 2006·Circulation Research·Richard A Cohen, Mark E McComb
Aug 4, 2007·Journal of Applied Physiology·David A LiemPeipei Ping
Jun 19, 2009·Expert Opinion on Therapeutic Targets·Ioanna AndreadouDimitrios Th Kremastinos
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Kerstin BoenglerRainer Schulz
Feb 7, 2015·Journal of Cardiovascular Pharmacology·Víctor M ParraRaúl J Domenech
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Shabaz A HamidGary F Baxter
Apr 5, 2017·Journal of the Saudi Heart Association·Ahsas Goyal, Neetu Agrawal
Aug 11, 2007·Journal of Applied Physiology·Andre TerzicScott A Waldman
Mar 29, 2014·Experimental Biology and Medicine·Claudia PennaPasquale Pagliaro

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.