PMID: 11342892May 9, 2001Paper

Reducing mucus production after urinary reconstruction: a prospective randomized trial

The Journal of Urology
J N'DowJ P Pearson

Abstract

After transposition into the urinary tract, intestinal segments continue to produce mucus. We determine the effectiveness of muco-regulatory drugs, including N-acetylcysteine, aspirin and ranitidine, in reducing mucus secretion and urine viscosity in patients with transposed segments. Our trial was a prospective randomized, double-blind placebo controlled crossover study involving 12 patients who underwent ileal conduit and 31 who underwent bladder reconstruction. Each treatment lasted 3 weeks with a 2-week washout. Pretreatment and posttreatment 24-hour urine samples were analyzed for mucin and viscosity after papain digestion, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and periodic acid-Schiff assay. A disease specific questionnaire and SF-36 quality of life survey were completed. According to the questionnaire, mucus production did not decrease with time in 67% of patients. Mucin comprised 3% of the total nondialyzable material in urine (65 mg./24-hour for ileal conduit and 60 mg./24-hour for bladder reconstruction). Analysis of questionnaires and laboratory results failed to demonstrate any benefit of taking muco-regulatory agents compared with placebo. The use of N-acetylcysteine, aspirin and ranitidine did ...Continue Reading

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Citations

Mar 9, 2006·Urological Research·W G Robertson, C R J Woodhouse
Aug 4, 2004·World Journal of Urology·James N'DowDavid Neal
Sep 7, 2004·World Journal of Urology·Christopher R J Woodhouse, William G Robertson
Apr 17, 2010·Bulletin of Experimental Biology and Medicine·A B StroganovI A Samsonov
Jan 10, 2003·BJU International·E W GerharzC R J Woodhouse
Oct 9, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sophia T Tragoulias, Philip J Anderton
Feb 7, 2007·Urology·UNKNOWN World Health Organization (WHO) Consensus Conference on Bladder CancerBjoern G Volkmer
Feb 21, 2008·BJU International·Rizwan HamidChristopher R J Woodhouse
Apr 27, 2016·Urolithiasis·Jai H SethSeshadri Sriprasad
May 10, 2005·The Journal of Urology·J N'DowJ P Pearson
Mar 3, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Wendy M CovertGinger D Langley
Apr 16, 2002·Current Opinion in Urology·Suzie Venn, Tony Mundy
Jun 20, 2002·Current Opinion in Urology·Darren T Beiko, Hassan Razvi

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