Reducing multiple births in assisted reproduction technology

Best Practice & Research. Clinical Obstetrics & Gynaecology
Siladitya Bhattacharya, Mohan S Kamath

Abstract

Multiple pregnancy, a complication of assisted reproduction technology, is associated with poorer maternal and perinatal outcomes. The primary reason behind this is the strategy of replacing more than one embryo during an assisted reproduction technology cycle to maximise pregnancy rates. The solution to this problem is to reduce the number of embryos transferred during in-vitro fertilisation. The transition from triple- to double-embryo transfer, which decreased the risk of triplets without compromising pregnancy rates, was easily implemented. The adoption of a single embryo transfer policy has been slow because of concerns about impaired pregnancy rates in a fresh assisted reproduction technology cycle. Widespread availability of effective cryopreservation programmes means that elective single embryo transfer, along with subsequent frozen embryo transfers, could provide a way forward. Any such strategy will need to consider couples' preferences and existing funding policies, both of which have a profound influence on decision making around embryo transfer.

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Citations

Apr 23, 2014·Current Opinion in Obstetrics & Gynecology·Necati Findikli, Engin Oral
Dec 23, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Veronica SaraisEdgardo Somigliana
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Aug 24, 2019·Journal of Assisted Reproduction and Genetics·Jose Moreno-Sepulveda, Miguel A Checa
Oct 3, 2019·Journal of Human Reproductive Sciences·Sesh Kamal SunkaraMohan S Kamath
Jun 22, 2017·Birth Defects Research·Rebecca F LibermanMarlene Anderka

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