Abstract
Ovarian cancer is a leading cause of cancer-related deaths among women. Given the low prevalence of this disease, the effectiveness of screening strategies has not been established. We wished to estimate the clinical impact and cost-effectiveness of potential screening strategies for ovarian cancer using population-specific data. A Markov state transition model to simulate the natural history of ovarian cancer in a cohort of women age 20 to 100. Age-specific incidence and mortality rates were obtained from SEER. Base-case characteristics of a potential screening test were sensitivity 85%, specificity 95%, and cost $50. Outcome measures were mortality reduction, lifetime number of false positive screening tests, positive predictive value, years of life saved (YLS), lifetime costs in US dollars, and incremental cost-effectiveness ratios (ICER, in cost/YLS). Model-predicted lifetime risk of ovarian cancer (1.38%), lifetime risk of death from ovarian cancer (0.95%), and stage distribution (stage I-19%; stage II-7%; stage III, IV, or unstaged - 74%) closely approximated SEER data. Annual screening resulted in 43% reduction in ovarian cancer mortality, with ICER of $73,469/YLS (base case) and $36,025/YLS (high-risk population) compar...Continue Reading
References
Jan 1, 1991·Journal of Clinical Epidemiology·S J Skates, D E Singer
Aug 1, 1985·American Journal of Obstetrics and Gynecology·P A WingoH B Peterson
Jun 1, 1993·Annals of Internal Medicine·M M SchapiraM J Young
Apr 17, 1993·BMJ : British Medical Journal·I JacobsD Oram
Jun 1, 1997·Controlled Clinical Trials·N UrbanC Colby
Apr 27, 1999·Lancet·I J JacobsD H Oram
Jul 25, 2000·American Journal of Epidemiology·E R MyersD B Matchar
Oct 24, 2000·Obstetrics and Gynecology·E R MyersD B Matchar
Feb 1, 2003·The Breast Journal·Kevin S HughesErica Edell
Sep 24, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J SkatesRobert C Bast
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Usha MenonIan J Jacobs
Nov 2, 2005·American Journal of Obstetrics and Gynecology·Saundra S BuysUNKNOWN PLCO Project Team
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Oct 10, 2006·Annals of Epidemiology·Ray M Merrill
Citations
Feb 22, 2012·Nanomedicine·Min ZhangTamara Minko
Feb 17, 2010·Journal of Women's Health·Sean M DevlinWilliam E Lafferty
Mar 5, 2011·Cancer Prevention Research·Phuong L MaiMark H Greene
Jul 20, 2011·Annals of Internal Medicine·Uri LadabaumKathryn A Phillips
Jun 29, 2010·Nursing for Women's Health·Sandra Cesario
Sep 11, 2012·Journal of Theoretical Biology·Kaveh DaneshEvan Myers
Dec 6, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Shalini Kulasingam, Laura Havrilesky
Jan 5, 2011·Journal of Minimally Invasive Gynecology·Archana Rao, Jonathan Carter
Jan 22, 2011·Cancer·Laura J HavrileskyEvan R Myers
Dec 7, 2016·BMC Medicine·Ben KearnsSusi Sadler
Sep 14, 2014·Journal of the National Cancer Institute·Clara BodelonMark E Sherman
Apr 13, 2013·International Journal of Molecular Sciences·Alan Kang-Wai MuAdawiyah Suriza Shuib
Apr 7, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vishal SharmaAndrew John Sutton
Jul 4, 2009·Menopause : the Journal of the North American Menopause Society·Robin J BellFrances Walker
Mar 6, 2019·Cancer·Robert C BastLee Zou
Nov 4, 2010·British Journal of Cancer·N B RettenmaierB H Goldstein
Jun 27, 2019·Cancer Causes & Control : CCC·Joellen M SchildkrautLynn Rosenberg
Jan 29, 2011·Cancer Control : Journal of the Moffitt Cancer Center·Gregory P Sfakianos, Laura J Havrilesky
Jul 8, 2017·BMC Cancer·Agata SwiatlyZenon J Kokot
Nov 1, 2012·Personalized Medicine·John E SchneiderDonald Chalfin
Feb 20, 2020·Cancer Prevention Research·Gaby SroczynskiUwe Siebert
Jun 24, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei-Lei YangUNKNOWN AOCS Study Group
Nov 19, 2010·Proteome Science·Siti S Abdullah-SoheimiAdawiyah S Shuib