Reducing radiation dose in rest-stress cardiac PET/CT by single poststress cine CT for attenuation correction: quantitative validation

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
K L GouldStefano Sdringola

Abstract

Cardiac PET/CT is optimized by cine CT with dedicated shift software for manual correction of attenuation-emission misregistration. Separate rest and stress CT scans incur greater radiation dose to patients than does standard helical PET/CT or "pure" PET using rotating rod attenuation sources. To reduce radiation dose, we tested quantitative accuracy of using a single poststress cine CT attenuation scan for reconstructing rest perfusion images to eliminate resting CT attenuation scans. A total of 250 consecutive patients underwent diagnostic rest-dipyridamole myocardial perfusion PET/CT with (82)Rb and a 16-slice PET/CT scanner using averaged cine CT attenuation data during breathing at rest and stress. After correcting for any attenuation-emission misregistration, we quantitatively compared resting perfusion images reconstructed using rest cine CT attenuation data with the same resting emission data reconstructed with poststress cine CT attenuation data. Automated software quantifying average regional quadrant activity, severity, size, and combined size and severity of perfusion defects was used for this comparison. Resting perfusion images reconstructed using rest cine CT attenuation data were quantitatively comparable to res...Continue Reading

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Citations

Dec 25, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nils P JohnsonK Lance Gould
May 10, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jonathon A Nye, Tracy L Faber
Jul 12, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ibrahim DanadPaul Knaapen
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jianye DaiAiping Lu
Dec 17, 2008·Medical Physics·Tinsu Pan, Osama Mawlawi
Jan 8, 2016·Current Cardiology Reports·K Lance Gould, Nils P Johnson
Feb 9, 2013·IEEE Transactions on Bio-medical Engineering·Greta S P MokMang I Vai
Mar 13, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stephan G Nekolla, Axel Martinez-Möller
Feb 24, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Piotr J SlomkaDaniel Berman
Aug 15, 2009·JACC. Cardiovascular Imaging·K Lance Gould
Apr 16, 2013·JACC. Cardiovascular Imaging·Andres F VasquezK Lance Gould
Nov 17, 2012·JACC. Cardiovascular Imaging·Nils P Johnson, K Lance Gould
Sep 18, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·K Lance Gould
May 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Qi ShiWei Wang
Apr 21, 2019·Medical Physics·Juan P Cruz-BastidaGuang-Hong Chen
Feb 26, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·K Lance GouldNils P Johnson
Nov 20, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R Glenn WellsTerrence D Ruddy
May 30, 2021·Seminars in Nuclear Medicine·Vasvi Singh, Sharmila Dorbala

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