Reducing recurrence in non-muscle-invasive bladder cancer using photodynamic diagnosis and immediate post-transurethral resection of the bladder chemoprophylaxis

Scandinavian Journal of Urology
Malene Risager LykkeKarsten Zieger

Abstract

The aim of this study was to evaluate the effect of fluorescence cystoscopy and immediate post-transurethral resection of the bladder (TURB) chemoprophylaxis on the risk of recurrence of non-muscle-invasive bladder cancer (NMIBC) under routine clinical conditions. Fluorescence cystoscopy using hexyl-aminolevulinate and post-TURB chemoprophylaxis using mitomycin C were simultaneously introduced in an effort to reduce the recurrence of NMIBC. In total, 190 consecutive patients were enrolled over a 2 year period and followed as the intervention group; 216 patients treated over a 2 year period before introduction served as controls. An intention-to-treat analysis was performed with baseline control. The recurrence risk was reduced by 41% (hazard ratio 0.59, 95% confidence interval 0.45-0.78) (intention-to-treat analysis). Median recurrence-free survival was extended from 13.6 months to 36.8 months. Every third follow-up TURB was avoided. Patients with low-risk tumors and patients with primary as well as recurrent disease benefited from the treatment. Fluorescence cystoscopy and immediate post-TURB chemoprophylaxis effectively reduced the recurrence risk and numbers of follow-up procedures under clinical routine conditions.

References

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Citations

Dec 13, 2016·Current Opinion in Urology·Esmee Iml Liem, Theo M de Reijke
Jul 13, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasushi NakaiKiyohide Fujimoto
Apr 4, 2018·International Urology and Nephrology·Deepak BaturaJosie Colemeadow
May 26, 2017·Scandinavian Journal of Urology·Per-Uno MalmströmGregers G Hermann

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