Reducing seroma formation with fibrin glue in an animal mastectomy model

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
E EroğluM Tilmaz

Abstract

Mastectomy is a frequently performed surgical procedure which has some important complications that may prolong hospital stay. Seroma formation after mastectomies and axillary dissection has an incidence of 5.8-53%. A new technique for preventing seroma formation was studied in an animal mastectomy model. Radical mastectomy was performed in guinea pigs. A control group of 20 animals had no further procedure post-mastectomy other than drying the wound with sterile gauze. In the other group fibrin glue was topically applied to prevent seroma formation to the operative field. Ten days after the operation, necropsy was performed and fluid collections were drained with an 18-gauge needle. The results were statistically analysed with a Two-sample rank-sum test. A significant difference existed between Groups I and II (P < 0.00005). It is concluded that fibrin glue can be used to prevent seroma formation after mastectomies.

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Citations

Nov 7, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C J PogsonS R Ebbs
Sep 26, 2008·Tissue Engineering. Part B, Reviews·Peter N Zawaneh, David Putnam
Feb 5, 2008·Gynécologie, obstétrique & fertilité·N DouayE Barranger
Jun 20, 2014·Future Oncology·E Jane H TurnerZoë E Winters
Jan 4, 2007·ANZ Journal of Surgery·Amit AgrawalKwok Leung Cheung
Nov 4, 2000·Expert Opinion on Investigational Drugs·R A Clark
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Muhammad S SajidRiccardo Bonomi
Jan 25, 2013·Journal of breast cancer·Vivek SrivastavaVijay Kumar Shukla

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