Reducing the cytotoxicity of inhalable engineered nanoparticles via in situ passivation with biocompatible materials

Journal of Hazardous Materials
Jeong Hoon ByeonJeffrey T Roberts

Abstract

The cytotoxicity of model welding nanoparticles was modulated through in situ passivation with soluble biocompatible materials. A passivation process consisting of a spark discharge particle generator coupled to a collison atomizer as a co-flow or counter-flow configuration was used to incorporate the model nanoparticles with chitosan. The tested model welding nanoparticles are inhaled and that A549 cells are a human lung epithelial cell line. Measurements of in vitro cytotoxicity in A549 cells revealed that the passivated nanoparticles had a lower cytotoxicity (>65% in average cell viability, counter-flow) than the untreated model nanoparticles. Moreover, the co-flow incorporation between the nanoparticles and chitosan induced passivation of the nanoparticles, and the average cell viability increased by >80% compared to the model welding nanoparticles. As a more convenient way (additional chitosan generation and incorporation devices may not be required), other passivation strategies through a modification of the welding rod with chitosan adhesive and graphite paste did also enhance average cell viability (>58%). The approach outlined in this work is potentially generalizable as a new platform, using only biocompatible materia...Continue Reading

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Citations

Oct 24, 2017·Nanotoxicology·Bijay Kumar PoudelJeong Hoon Byeon
Nov 7, 2019·ACS Nano·Milan GautamJeong Hoon Byeon

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