Reducing the frequency of respiratory tract infections in severe neurological disorders by inhaled antibiotics: a retrospective data analysis

ERJ Open Research
Maximilian EckerlandFlorian Stehling

Abstract

In patients with severe neurological impairment, recurrent respiratory tract infections frequently occur as a result of impaired clearance of airway secretions and microbial airway colonisation. We hypothesised that inhaled antibiotic therapy may improve the morbidity of these patients. A retrospective data analysis of 20 patients (11 nontracheotomised and nine tracheotomised) with neurological impairment and microbial airway colonisation was carried out at a children's university hospital. Two questionnaires that asked about the number of respiratory tract infections, antibiotic therapies and hospitalisations were distributed to the patients/caregivers: a first questionnaire representing the 12 months prior to the initiation of inhaled antibiotics and a second questionnaire describing the first 12 months under therapy. During the first 12 months of therapy, the frequency of respiratory tract infections among all participants was reduced from a mean of 6.8 episodes (median (interquartile range (IQR)) 6.0 (4.0-10.0) episodes) to a mean of 2.5 episodes (median (IQR) 2.0 (1.0-3.0) episodes; p<0.001). In addition, a significant decrease of systemic antibiotic therapies (mean 7.7, median (IQR) 6.0 (4.0-10.0) versus 2.5, 2.5 (0.0-3.7...Continue Reading

References

Jul 1, 1988·The American Review of Respiratory Disease·A Mier-JedrzejowiczM Green
Jun 17, 1993·The New England Journal of Medicine·B W RamseyM A McBurnie
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·T L BonfieldM Berger
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J M PoponickA F DiMarco
Sep 25, 2001·Pediatric Pulmonology·V B Pai, M C Nahata
Mar 17, 2004·Pediatric Pulmonology·M GrieseT Nicolai
Aug 11, 2004·American Journal of Respiratory and Critical Care Medicine·Jonathan D FinderUNKNOWN American Thoracic Society
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gerd DöringUNKNOWN Consensus Study Group
Apr 20, 2006·Neuromuscular Disorders : NMD·C Dohna-SchwakeU Mellies
Dec 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kentigern ThorburnHendrick K F van Saene
Sep 21, 2011·European Journal of Pediatrics·Corrie E ErasmusPeter H Jongerius
Oct 1, 2011·Journal of Pediatric Rehabilitation Medicine·Audrius V Plioplys, Irene Kasnicka
Jun 14, 2014·The European Respiratory Journal·Alessandra Monteiro BrodtLinjie Zhang
Nov 5, 2014·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Mary Lou SoleJason Wilson
Dec 17, 2015·Respiratory Care·Rachael McCalebCatherine E O'Brien
May 26, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Florian StehlingUwe Mellies
Jul 16, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andre C KalilJan L Brozek
Oct 18, 2016·American Journal of Respiratory and Critical Care Medicine·Kenneth N OlivierRichard J Wallace
Apr 4, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Grazia Crescimanno, Oreste Marrone
Apr 4, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Florian StehlingUwe Mellies
Apr 26, 2017·Pediatric Pulmonology·Christopher J RussellMichael N Neely
May 27, 2017·Respiratory Care·Howard B Panitch
Mar 5, 2018·Respiratory Medicine·Michelle ChatwinBrenda M Morrow
Mar 7, 2018·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Carlo CastellaniPavel Drevinek
Jul 4, 2018·Pediatric Pulmonology·Catherine D SandersCharles R Esther

❮ Previous
Next ❯

Citations

Mar 14, 2021·International Journal of Pediatric Otorhinolaryngology·Emine AtagSedat Oktem
Mar 30, 2021·ERJ Open Research·Hui-Leng Tan, Elaine Chan

❮ Previous
Next ❯

Software Mentioned

VACTERL
Prism
SPSS
GraphPad

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.