Reducing the risk of fetal distress with sildenafil study (RIDSTRESS): a double-blind randomised control trial

Journal of Translational Medicine
Liam DunnSailesh Kumar

Abstract

Labour is perhaps the most hazardous time in pregnancy. As many as 20 % of cerebral palsy cases in term infants result from intrapartum events and up to 63 % of babies who develop intrapartum compromise have no prior risk factors. Sildenafil citrate (SC), a phosphodiesterase 5 inhibitor, improves uterine blood supply through vasodilatation and potentially could improve placental perfusion and hence reduce the risk of intrapartum fetal hypoxia. The aim of this study is to evaluate the efficacy of SC to reduce the risk of intrapartum fetal compromise and the need for emergency operative delivery. This is a single centre, double-blind, randomised, phase II clinical trial of SC or placebo given during labour to women (18-50 years of age) with a single, appropriately grown, non-anomalous baby at term (37-42 weeks gestation). Those with cardiovascular, renal, hepatic, ocular or hypertensive disease or contraindication to SC will be excluded. Participants will be randomised to either SC 50 mg or placebo capsules eight hourly (SC maximum 150 mg) to commence when admitted to birth suite for management of labour. Within 3 h of the first dose, a repeat ultrasound scan will be performed to measure any changes in uteroplacental and fetal Do...Continue Reading

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Citations

Jul 19, 2018·Current Treatment Options in Cardiovascular Medicine·Kate M CohenLisa R Leffert
Dec 27, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Francesca M RussoKarel Allegaert
Mar 22, 2019·Current Pharmaceutical Design·Francesca M RussoJan Deprest
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Oct 13, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jessica TurnerSailesh Kumar
Jun 12, 2021·Frontiers in Pediatrics·María Luisa Mayol PérezPaloma Echevarría Pérez
Nov 25, 2017·Seminars in Fetal & Neonatal Medicine·Francesca Maria RussoJan Deprest

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