Reducing the risk of transfusion-transmissible viral infection through blood donor selection: the Australian experience 2000 through 2006

Mark N PolizzottoAustralian Red Cross Blood Service Donor and Product Safety Team


Selection of voluntary donors who are at low risk of transfusion-transmissible viral infection (TTVI) is central in maintaining the safety of the blood supply. Evaluation of its effectiveness and the dynamics of the process may offer opportunities to further improve transfusion safety. The impact of donor selection on prevalence of TTVI was analyzed in all allogeneic donations in Australia between July 2000 and June 2006 by interviewing donors found to have a TTVI. The presence and disclosure of infective risks was reassessed. A total of 6.3 million donations were tested; of these, 1,449 (0.02%) were repeat-reactive for a TTVI and were discarded. This comprised 605 (42%) positive for the presence of hepatitis B, 818 (56%) positive for the presence of hepatitis C, 18 (1%) positive for the presence of human immunodeficiency virus, and 20 (1%) positive for the presence of human T-cell lymphotropic virus-I and/or -II (HTLV-I/II). This prevalence was 50 to 350 times lower than in the Australian population. In 1,158 cases (80%), an infective risk was identified; 509 donors (44%) had more than one. The most common identified were country of birth and parental ethnicity (n = 682, 26% of risks), tattoos and/or piercings (n = 448, 18%), ...Continue Reading


Aug 17, 1992·The Medical Journal of Australia·J M KaldorB R Wylie
Feb 22, 1992·Lancet·M J GoodrickV Pearson
Oct 1, 1991·Transfusion·J W Mosley
Apr 1, 1983·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Jun 27, 1996·The New England Journal of Medicine·G B SchreiberJ J Korelitz
Jun 27, 1996·The New England Journal of Medicine·C Conry-CantilenaJ W Shih
Mar 1, 1996·Transfusion Medicine·F M CowanM Brennan
Mar 26, 1997·JAMA : the Journal of the American Medical Association·A E WilliamsG J Nemo
Jun 2, 1997·The Medical Journal of Australia·G S Whyte, H F Savoia
Jun 2, 1997·The Medical Journal of Australia·G S Whyte, H F Savoia
Feb 12, 1998·Annals of Internal Medicine·J P AuBuchonM P Busch
Jul 24, 1998·Transfusion Medicine·D VoakM C Contreras
Aug 15, 1998·Vox Sanguinis·P J van den BurgH W Reesink
Jan 30, 1999·Transfusion Medicine Reviews·V JamesJ A Barbara
Jan 5, 2002·Transfusion·H StigumP Magnus
Sep 11, 2002·Transfusion Medicine·P R Grant, M P Busch
Feb 1, 2003·Transfusion·Ana M SanchezUNKNOWN Retrovirus Epidemiology Donor Study
Jul 19, 2003·Transfusion·S E Rugege-HakizaUNKNOWN Retrovirus Epidemiology Donor Study
May 4, 2004·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J PillonelUNKNOWN Centre de transfusion sanguine des armées
Feb 15, 2005·Australian and New Zealand Journal of Public Health·Belinda G O'SullivanGregory J Dore
Dec 24, 2005·British Journal of Haematology·Christopher A Ludlam, Marc L Turner
Jan 31, 2006·Transfusion·Richard FieldingAnthony Hedley
May 3, 2006·Pediatric Hematology and Oncology·Hüseyin GülenCanan Vergin
Nov 15, 2006·International Journal of Health Care Quality Assurance Incorporating Leadership in Health Services·Paulo SousaHelle Wijk
Dec 21, 2006·Transfusion·Susan P MontgomeryUNKNOWN 2003 West Nile Virus Transfusion-Associated Transmission Investigation Team

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Oct 14, 2011·Viruses·Sabrina M RodríguezLuc Willems
Oct 23, 2013·The Journal of Hospital Infection·P A GhareebW T McClellan
Jan 10, 2018·Journal of Medical Virology·Alessia LaiMassimo Ciccozzi
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Jul 4, 2019·Transfusion·Suchitra Pandey, Hua Shan

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