Reducing the risk of transfusion-transmissible viral infection through blood donor selection: the Australian experience 2000 through 2006

Transfusion
Mark N PolizzottoAustralian Red Cross Blood Service Donor and Product Safety Team

Abstract

Selection of voluntary donors who are at low risk of transfusion-transmissible viral infection (TTVI) is central in maintaining the safety of the blood supply. Evaluation of its effectiveness and the dynamics of the process may offer opportunities to further improve transfusion safety. The impact of donor selection on prevalence of TTVI was analyzed in all allogeneic donations in Australia between July 2000 and June 2006 by interviewing donors found to have a TTVI. The presence and disclosure of infective risks was reassessed. A total of 6.3 million donations were tested; of these, 1,449 (0.02%) were repeat-reactive for a TTVI and were discarded. This comprised 605 (42%) positive for the presence of hepatitis B, 818 (56%) positive for the presence of hepatitis C, 18 (1%) positive for the presence of human immunodeficiency virus, and 20 (1%) positive for the presence of human T-cell lymphotropic virus-I and/or -II (HTLV-I/II). This prevalence was 50 to 350 times lower than in the Australian population. In 1,158 cases (80%), an infective risk was identified; 509 donors (44%) had more than one. The most common identified were country of birth and parental ethnicity (n = 682, 26% of risks), tattoos and/or piercings (n = 448, 18%), ...Continue Reading

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Citations

Oct 14, 2011·Viruses·Sabrina M RodríguezLuc Willems
Oct 23, 2013·The Journal of Hospital Infection·P A GhareebW T McClellan
Jan 10, 2018·Journal of Medical Virology·Alessia LaiMassimo Ciccozzi
Mar 9, 2018·Frontiers in Medicine·Daniel Candotti, Syria Laperche
Jul 4, 2019·Transfusion·Suchitra Pandey, Hua Shan

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