Reduction by beta-adrenoceptor blockade of hypoxia-induced right heart hypertrophy in the rat

British Journal of Pharmacology
I Ostman-Smith

Abstract

1. The study was undertaken to assess the role of beta-adrenoceptors in the induction of compensatory cardiac hypertrophy in an in vivo model. 2. In the rat, exposure to severe hypoxia (6% inspired oxygen for 8 h day) caused a 51% increase in right heart weight and a 75% increase in haematocrit. 3. The hypoxia-induced right ventricular hypertrophic response was reduced by 65% by oral treatment with a high dose of the non-selective beta-adrenoceptor antagonist, propranolol (80 mg kg-1 body weight); the drug treatment caused only a minor reduction (6%) in secondary polycythaemia. 4. With a less severe degree of hypoxia (7% inspired oxygen) there was only minimal secondary polycythaemia (+15%), and a lesser degree of compensatory right ventricular hypertrophy in untreated rats (+33%). 5. Treatment with the beta 1-adrenoceptor antagonist, atenolol, in a dose of 80 mg kg-1 body weight abolished right ventricular hypertrophy in response to 7% inspired oxygen, without affecting haematocrit and caused a small reduction in the ratio of heart weight to body weight in normoxic rats. 6. The results show that the effect of propranolol on hypoxic right ventricular hypertrophy is not secondary to any effect on secondary polycythaemia as has p...Continue Reading

References

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Citations

Apr 28, 2006·Pflügers Archiv : European journal of physiology·L TualJ-P Richalet
Oct 2, 2003·European Journal of Pharmacology·Bronwyn J Thomas, Janet C Wanstall
Apr 20, 2007·Respiratory Physiology & Neurobiology·B Ostadal, F Kolar
Sep 14, 1999·Journal of the American College of Cardiology·F Alfonso, W J McKenna

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