Reduction by cobra venom factor of myocardial necrosis after coronary artery occlusion

The Journal of Clinical Investigation
P R MarokoS L Hale

Abstract

Components of the complement system are known to play an important role in the cytolytic process and in chemotaxis of leukocytes. Cobra venom factor specifically cleaves C3 activity via activation of the alternative (properdin) complement pathway. It does not act directly on C3. If C3 is involved in tissue necrosis after ischemic injury, cobra venom factor might reduce tissue damage after acute coronary occlusion. Accordingly, in 14 control dogs occlusion of the left anterior descending artery was carried out for 24 h. Epicardial electrograms were recorded 15 min after occlusion, and 24 h later transmural specimens for creatine phosphokinase activity (CPK) and for histological analysis were obtained from the same sites. In another 14 experimental dogs, 20 U/kg cobra venom factor was given intravenously 30 min after occlusion. Serum complement levels fell within 2-4 h to <20% of normal. In the control dogs, the relationship between ST-segment elevation and CPK activity 24 h later was: log CPK = -0.06 ST + 1.48 (n = 111 specimens, 14 dogs, r = 0.77). In the experimental dogs, log CPK = -0.024 ST + 1.46 (n = 111 specimens, 14 dogs, r = 0.60), showing significantly different slopes (P < 0.001), i.e., less CPK depression for any lev...Continue Reading

References

Jan 1, 1975·Circulation·J T FlahertyB Pitt
Nov 1, 1973·Annals of Internal Medicine·P R Maroko, E Braunwald
Jul 1, 1970·The Journal of Immunology : Official Journal of the American Association of Immunologists·C G CochraneB S Aikin
Sep 14, 1972·The New England Journal of Medicine·S RuddyK F Austen
May 1, 1972·Cardiovascular Research·L J PelidesJ P Shillingford
Mar 1, 1973·The Journal of Clinical Investigation·P LibbyE Braunwald
Jan 17, 1974·The New England Journal of Medicine·P R Maroko
Jan 1, 1974·The Journal of Experimental Medicine·O Götze, H J Müller-Eberhard
Nov 1, 1969·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Ballow, C G Cochrane
Apr 1, 1971·The Journal of Experimental Medicine·J H Hill, P A Ward
Jul 15, 1971·The New England Journal of Medicine·D L PageC A Sanders
Jul 1, 1970·British Heart Journal·C HanarayanB L Pentecost

❮ Previous
Next ❯

Citations

Apr 1, 1997·Virchows Archiv : an International Journal of Pathology·T TadaT Eimoto
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A ZimmermannH Isliker
Jan 1, 1994·Springer Seminars in Immunopathology·K R KalliD T Fearon
Jan 1, 1987·Basic Research in Cardiology·G J Grover, H R Weiss
Feb 1, 1993·The International Journal of Biochemistry·T Siminiak, T Ozawa
Mar 9, 1990·Journal of Immunological Methods·M PascualJ A Schifferli
Aug 1, 1995·Immunopharmacology·M GardinaliA Agostoni
Jun 1, 1988·Journal of the American College of Cardiology·J L MehtaP Mehta
Mar 1, 1983·The American Journal of Cardiology·P WalinskyL Wiener
May 16, 1998·The Annals of Thoracic Surgery·H L LazarR J Shemin
Mar 4, 2000·Molecular Immunology·C D CollardG L Stahl
Feb 26, 1998·Immunopharmacology·B R Lucchesi, K S Kilgore
Jan 1, 1996·Pharmacology & Therapeutics·F M Williams
Feb 1, 1997·International Journal of Cardiology·J KowalskiJ Paśnik
Apr 4, 1998·Brain Research Bulletin·U S VasthareR F Tuma
Aug 21, 2003·Forensic Science International : Synergy·Armin FieguthWerner Johann Kleemann
Sep 1, 1987·Journal of the American College of Cardiology·W R BennettR Bolli
Jun 4, 1998·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·S P CavanaghS Homer-Vanniasinkam
Sep 1, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·W M BaldwinR H Hruban
May 23, 2001·International Immunopharmacology·R NijmeijerC E Hack
Apr 3, 1980·The New England Journal of Medicine·H S JacobC F Moldow
Dec 22, 1999·The Journal of Experimental Medicine·M GriselliM B Pepys
Oct 13, 2006·Antioxidants & Redox Signaling·Nikolaos G Frangogiannis
Apr 1, 1989·Annals of Surgery·J M KlausnerH B Hechtman
May 29, 2009·Annals of Surgery·Gwendolyn M P DiepenhorstC Erik Hack
Mar 3, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Väkevä, S Meri
Jul 16, 2010·American Journal of Physiology. Cell Physiology·Yan FengWei Chao
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yan FengWei Chao
Nov 18, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Wei Chao
Nov 1, 1980·The Journal of Clinical Investigation·R N PinckardM S Olson
Aug 1, 1989·The Journal of Clinical Investigation·M K Hostetter, G M Johnson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.