Reduction by oral propranolol treatment of left ventricular hypertrophy secondary to pressure-overload in the rat

British Journal of Pharmacology
I Ostman-Smith

Abstract

1. Studies on cardiac myocyte cell cultures have postulated a role for alpha 1-adrenoceptors and mechanical stretch in the induction of cellular changes thought to be important in compensatory cardiac hypertrophy. However, in vivo work suggests that beta-adrenoceptors are important and the present study was designed to analyse the effect of propranolol on the cardiac hypertrophy caused by a pressure-overload in a way that takes account of the effects of propranolol on the work load itself. 2. The compensatory cardiac hypertrophy that develops in response to experimental coarctation of the aorta was studied in the rat. Pressure gradients and total cardiac work load (expressed as rate x pressure product) were assessed, and the relationship between increasing cardiac work load and the resulting left ventricular hypertrophy was established in a control group and compared with left ventricular hypertrophy in a group treated with a high dose of oral propranolol (80 mg kg-1 body weight). 3. In the rats with mean pressure gradients over the coarctation in the range of 15-31 mmHg, the animals on control diet showed a 38% increase in left ventricular weight/body weight ratio (LV ratio) and a 30% increase in heart weight/body weight ratio...Continue Reading

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Citations

May 28, 2011·British Journal of Pharmacology·Marco MusumeciGiuseppe Marano
Sep 14, 1999·Journal of the American College of Cardiology·F Alfonso, W J McKenna
May 5, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Raffaele CoppiniKarel Allegaert
Dec 27, 2005·Expert Review of Cardiovascular Therapy·Hans Henrik Odland, Erik M D Thaulow
Oct 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Stephen W LuckeyLeslie A Leinwand

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