Reduction in alkaline sphingomyelinase in colorectal tumorigenesis is not related to the APC gene mutation

International Journal of Colorectal Disease
E HertervigRui-Dong Duan

Abstract

The sphingomyelin pathway is an important intracellular mechanism in regulating cell growth. The first step in this pathway is catalysed by sphingomyelinases. Alkaline sphingomyelinase is specifically located in the intestinal tract. Markedly reduced alkaline sphingomyelinase activities have been found in sporadic colorectal tumours and in familial adenomatous polyposis adenomas. Since the adenomatous polyposis coli (APC) gene is mutated in about 80% of sporadic colorectal tumors, and familial adenomatous polyposis is the consequence of a germline mutation of the same gene, we examined whether low alkaline sphingomyelinase activity is linked to APC gene mutations. Both germline and sporadic adenomatous polyposis coli gene mutations were studied. Alkaline, neutral, and acid sphingomyelinase activities were measured in the intestinal mucosa and content of multiple intestinal neoplasia mice, a murine model of familial adenomatous polyposis and compared to control mice. Alkaline sphingomyelinase activity was also measured in 11 human rectal tumors with APC gene mutation and compared with 9 control tumors without mutation. Alkaline, neutral, and acid sphingomyelinase activities were present in the small intestine and colon in both m...Continue Reading

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Citations

Sep 19, 2006·Molecular and Cellular Biology·Masataka KohnoTimothy Hla
Dec 6, 2019·International Journal of Molecular Sciences·Miroslav MachalaJan Vondráček
Feb 24, 2021·Bioscience Reports·Zoë JukesJia V Li

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