Reduction in antiviral activity of human beta interferon by gallic acid.

Infection and Immunity
L C OsborneD L Archer

Abstract

Gallic acid (GA) is a common part of the human diet, both in the free form and as a metabolite of tannic acid and propyl gallate. Cell cultures were incubated with mixtures of either GA and beta interferon (IFN-beta) (formerly fibroblast IFN) or medium and IFN-beta. The cells were subsequently challenged with virus. The virus plaque yields were greater in cells incubated with IFN-beta and GA than in cells incubated with IFN-beta and medium, indicating that in the former mixture, IFN-beta had lost antiviral activity. The magnitude of the loss was dependent upon the GA concentration. IFN-alpha and IFN-gamma (formerly leukocyte IFN and immune IFN, respectively) were not similarly affected. The effect of GA on IFN-beta could be reversed with 2-mercaptoethanol, suggesting a possible sulfhydryl involvement. Extensive dialysis of IFN-beta-GA mixtures to remove the GA failed to reverse the reduction in antiviral activity. This suggests that a direct and irreversible interaction between IFN-beta and GA took place, reducing the activity of IFN-beta. The significance of this finding with regard to virus infections of the intestine is discussed.

References

May 1, 1978·Archives of Disease in Childhood·J Walker-Smith
Jan 1, 1979·Infection and Immunity·L C OsborneH M Johnson
Oct 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·F DianzaniM Zucca
Jul 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·H M Johnson
Jul 15, 1980·Cellular Immunology·L C OsborneH M Johnson
Feb 1, 1979·Journal of Food Protection·D O Cliver, K D Kostenbader

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Citations

Aug 1, 1986·Journal of Interferon Research·E OnishiS Yamazaki
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Nitin GuptaHitesh Kulhari

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