PMID: 11332570May 3, 2001Paper

Reduction in atrial defibrillation threshold by a single linear ablation lesion

Journal of Cardiovascular Electrophysiology
J B WhiteR E Ideker

Abstract

This study investigated a hybrid approach to reduce the atrial defibrillation threshold (ADFT) by determining the effect of a single linear radiofrequency ablation (RFA) lesion on both the ADFT and activation patterns during atrial fibrillation (AF). In 18 open chest sheep (45 to 57 kg), coil defibrillation electrodes were placed in a superior vena cava/right ventricular configuration. AF was induced by burst pacing and maintained with acetyl beta-methylcholine (2 to 42 microL/min). ADFTs were obtained before and after a linear RFA lesion was created in the left atrium (LAL; n = 6), right atrium (RAL; n = 6), or neither atrium as a control (n = 6). In animals receiving an LAL, a 504-unipolar-electrode plaque was sutured to the LA. For animals receiving an RAL, two 504-electrode plaques were placed, one each on the LA and RA. From each plaque, activations were recorded before and after ADFT shocks, and organizational characteristics of activations were analyzed using algorithms that track individual wavefronts. In sham-treated controls, the ADFT did not change. In contrast, LAL reduced ADFT energy 29%, from 4.5 +/- 2.3 J to 3.2 +/- 2.0 J (P < 0.05). RAL reduced ADFT energy 25%, from 2.0 +/- 0.9 J to 1.5 +/- 0.7 J (P < 0.05). AF ...Continue Reading

Citations

Aug 22, 2003·Journal of Cardiovascular Electrophysiology·Luigi PadelettiAndrea Grammatico
Sep 18, 2012·Pacing and Clinical Electrophysiology : PACE·Eui-Seock HwangHui-Nam Pak
Feb 15, 2002·Journal of Cardiovascular Electrophysiology·Carsten W IsraelStefan H Hohnloser
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Crystal M RipplingerIgor R Efimov

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