PMID: 6164436Mar 30, 1981Paper

Reduction in basal ganglia and substantia nigra substance P levels in Huntington's disease

Brain Research
S H BuckH I Yamamura

Abstract

Substance P (SP) levels were determined by radioimmunoassay (RIA) in several regions of post-mortem brain of controls and Huntington's disease (HD) patients. In controls, highest SP levels were found in basal ganglia, substantia nigra and hypothalamus. Nigral pars reticulata contained 3--4-fold higher levels than pars compacta. In HD, SP levels were reduced in all basal ganglia and substantia nigra. The reductions ranged from 48% in caudate nucleus to over 90% in nigral pars reticulata. There were no changes in SP levels in HD frontal cortex, thalamus or hypothalamus.

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Citations

Nov 4, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Deniz KirikPhilippe Hantraye
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