PMID: 43364Dec 1, 1979

Reduction in blood pressure in normal and spontaneously hypertensive rats by lergotrile mesylate

The Journal of Pharmacy and Pharmacology
A F Sved, J D Fernstrom


The acute administration of lergotrile mesylate to normal or spontaneously-hypertensive rats (SHR) causes a prompt reduction in blood pressure. In SHR, doses as small as 0.05 mg kg-1 are effective; maximal reductions in blood pressure are obtained at a dose of 0.25 mg kg-1. Lergotrile may be administered intraperitoneally or orally. Its efficacy as an antihypertensive agent in rats does not diminish significantly when administered twice daily for 7 days. Although lergotrile has been reported to be a dopamine agonist, the present data do not establish the mechanism by which the drug lowers blood pressure.


Jan 1, 1977·Journal of Neural Transmission·J Y LewM Goldstein
May 29, 1976·Lancet·S B KayeE J Ross
May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·R E ClearyL Lemberger
May 1, 1975·Neurology·A LiebermanM Goldstein
Jun 1, 1975·Acta Endocrinologica·J A ClemensC J Shaar
Feb 15, 1977·Biochemical Pharmacology·K StarkeE Browski
Sep 1, 1977·European Journal of Pharmacology·N C TyeI A Pullar
Jun 1, 1977·Journal of Neurochemistry·E K Silbergeld, R F Pfeiffer
Mar 17, 1977·The New England Journal of Medicine·D L KleinbergA G Frantz
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May 15, 1976·British Medical Journal·J SteinerA Breckenridge
Sep 1, 1974·The Journal of Clinical Endocrinology and Metabolism·L LembergerR T Woodburn

Related Concepts

Rats, Inbred SHR
Depression, Chemical
Diastolic Blood Pressure
Lergotrile mesylate
Hypertensive Disease
Antihypertensive Agents
Injections, Intraperitoneal
Blood Pressure
Dopaminergic Agonist [EPC]

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