PMID: 9179465Mar 1, 1997Paper

Reduction in body weight helps to delay the onset of diabetes even in non-obese with strong family history of the disease

Diabetes Research and Clinical Practice
M ViswanathanA Ramachandran

Abstract

Of the 1200 non-diabetic offspring of non-insulin-dependent diabetic patients registered under the prevention programme, 262 (M:F 189:73) were available for analysis with greater than or equal to 4 years of follow-up. All of them had been prescribed a calorie restricted diet to suit their body weight, occupation and age, and were advised to restrict the use of refined carbohydrates and fats. Regular exercise was also advised. Compliance with these prescriptions was assessed at each follow up. At the time of analysis, it was noted that only 14.5% had developed diabetes in a period of 8 +/- 4.2 years even though many of them had impaired glucose tolerance at entry in the programme. Multiple regression analysis showed that initial 2 h plasma glucose, initial glucose tolerance and gain in body weight were strong predictors of diabetes. Weight loss occurred in persons who adhered to diet and exercise programmes and conversion to diabetes was lower in them compared to those who gained weight (P < 0.002). Although the rate and degree of obesity is less among Indians, it has been observed in several earlier studies that even a minor increase in body mass index increased the risk of diabetes. This study highlights the fact that measures...Continue Reading

References

Dec 1, 1992·Diabetes/metabolism Reviews·J TuomilehtoP Zimmet
Jun 1, 1986·Diabetes Research and Clinical Practice·A RamachandranM Viswanathan
Nov 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·R J JarrettP McCartney
Apr 1, 1995·Diabetes·R L HansonW C Knowler
Jan 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·M PierceC Bradley
Feb 1, 1997·Diabetologia·A RamachandranM Viswanathan

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Citations

Mar 20, 2003·Current Diabetes Reports·E J Mayer-Davis, T Costacou
May 23, 2008·Journal of Human Hypertension·K P Vasisht, G Bakris
Mar 11, 2003·Annual Review of Nutrition·T Costacou, E J Mayer-Davis
Aug 10, 2000·Public Health Nutrition·R LappalainenS Paquet
Jan 19, 2007·Diabetes Research and Clinical Practice·Palany RaghupathyJoseph Richard
Aug 6, 2002·Diabetes Research and Clinical Practice·A RamachandranV Vijay
Feb 27, 1999·Preventive Medicine·R M MerrillE J Feuer
Apr 24, 2001·Diabetes Care·E J Mayer-Davis
Jul 4, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S RodovalhoL A Velloso
Nov 28, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L A SargeantK T Khaw

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