Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

European Journal of Nuclear Medicine and Molecular Imaging
Ralph BuchertHidehiro Iida

Abstract

Quantitative estimates of dopamine transporter availability, determined with [(123)I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [(123)I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis. Of 73 healthy subjects from the European Normal Control Database of [(123)I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific "to kBq/ml" calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [(123)I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occip...Continue Reading

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Citations

May 30, 2019·Annals of Nuclear Medicine·Toshiyuki HayashiKazumi Kimura
Oct 16, 2018·PloS One·M Martinez-GarciaJ Malo
Jan 19, 2018·Nuclear Medicine Communications·Jonathan C TaylorJohn Fenner
May 11, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Silvia MorbelliIan Law
May 30, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicolas NicastroValentina Garibotto
Jul 11, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alberto LleraChristian F Beckmann
Oct 3, 2018·Annals of Nuclear Medicine·Mahmudur G M RahmanHidehiko Okazawa
Nov 2, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Helen Schmitz-SteinkrügerRalph Buchert

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