PMID: 8597317Mar 15, 1996Paper

Reduction in carotid arterial wall thickness using lovastatin and dietary therapy: a randomized controlled clinical trial

Annals of Internal Medicine
H N HodisS P Azen

Abstract

To assess the effects of lipid-lowering therapy on the progression of early, preintrusive carotid arterial atherosclerosis. Randomized, double-blind, placebo-controlled, serial carotid arterial imaging trial. University Atherosclerosis Research Unit. 188 patients from the Monitored Atherosclerosis Regression Study who were 37 to 67 years of age and had angiographically defined coronary artery disease. Cholesterol-lowering diet plus placebo or lovastatin, 80 mg/d. High-resolution B-mode ultrasonographic quantification of the combined thickness of the distal common carotid arterial far wall intima-media complex (carotid arterial intima-media thickness) at baseline and every 6 months for as long as 4 years. The annual rate of change in carotid arterial intima-media thickness differed significantly between the lovastatin group and the placebo group at 2 and 4 years (P < 0.001). Lipid-lowering therapy reverses the progression of early, preintrusive atherosclerosis of the carotid artery. Both cholesterol-rich and triglyceride-rich lipoproteins correlate with the progression of early, preintrusive atherosclerosis of the carotid artery. These findings, together with earlier reports of the effects of lovastatin therapy on the progressio...Continue Reading

Associated Clinical Trials

Citations

Dec 21, 2000·Current Atherosclerosis Reports·B J Ansell
Jun 8, 2002·Current Atherosclerosis Reports·Joao A GomesViken L Babikian
Jan 5, 2002·Current Atherosclerosis Reports·Howard N HodisRoger Lobo
Dec 10, 2003·Current Atherosclerosis Reports·Samir N PatelSteven B Feinstein
Dec 20, 2012·Current Atherosclerosis Reports·Mukesh Singh, Updesh Singh Bedi
Dec 6, 2011·Current Treatment Options in Cardiovascular Medicine·P CostanzoP Perrone-Filardi
Sep 2, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Patrick J DevineAllen J Taylor
Sep 24, 2004·Oral Oncology·Olubunmi K Abayomi
Dec 26, 2001·Annals of Epidemiology·N David YanezUNKNOWN Cardiovascular Health Study
Apr 26, 2003·Atherosclerosis. Supplements·John J P KasteleinEric de Groot
Aug 3, 2000·The New England Journal of Medicine·H D WhiteA M Tonkin
Apr 1, 2008·The New England Journal of Medicine·John J P KasteleinUNKNOWN ENHANCE Investigators
Jun 9, 2009·European Heart Journal·Wolfgang SturmChristoph F Ebenbichler
Feb 1, 2002·Journal of Hypertension·Alain SimonJaime Levenson
Feb 19, 2000·Current Opinion in Lipidology·G F Watts, S B Dimmitt
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·C Wanner, T Quaschning
Jul 23, 2005·Menopause : the Journal of the North American Menopause Society·Roksana KarimHoward N Hodis
Dec 13, 2005·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Louis R Caplan, Norman R Hertzer
Nov 13, 2007·Current Opinion in Lipidology·Raphael DuivenvoordenJohn J P Kastelein
Sep 2, 2010·Topics in Magnetic Resonance Imaging : TMRI·Niranjan BaluChun Yuan
Jan 14, 2010·Ultrasound Quarterly·Joseph F Polak
Jul 22, 2005·International Journal of Clinical Practice·A AlevizosP Korantzopoulos
Jul 14, 2007·International Journal of Clinical Practice·Kosmas I ParaskevasD P Mikhailidis
Aug 27, 2005·American Journal of Respiratory and Critical Care Medicine·Kenji MinoguchiMitsuru Adachi
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerGeraldo Lorenzi-Filho
Nov 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·George NtaiosApostolos Hatzitolios
Jun 8, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Mariëlle G J DuffelsBarbara J M Mulder
May 3, 2013·Journal of Periodontology·Francesco D'AiutoJohn C Gunsolley
Jun 11, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Sanne A E PetersMichiel L Bots

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