Reduction in cervical intraepithelial neoplasia in young women in British Columbia after introduction of the HPV vaccine: An ecological analysis

International Journal of Cancer. Journal International Du Cancer
Gina S OgilvieAndrew J Coldman

Abstract

We report on the rates of cervical intraepithelial neoplasia (CIN) in young women aged 15-22 years of age in British Columbia before and after the introduction of an HPV vaccine program. Rates of cervical intraepithelial neoplasia (CIN) 2+ for each age stratum (15-22) in the calendar years 2004-2012 for the province of British Columbia were obtained from the BC Cancer Agency's population-based cervical cancer program. Incidence rate ratios (IRR) of CIN2+ were described and compared before and after HPV vaccine program introduction in cohorts born in vaccine eligible years, and in non-vaccine eligible years using piece-wise Poisson regression analysis, and adjusted for age. Between 2004 and 2012, rates of CIN2 and CIN2+ in young women aged 15-22 years in the province of British Columbia have decreased overall. After the introduction of the HPV vaccine program, the age adjusted IRR for CIN2+ for young women aged 15-17 years decreased significantly from 0.91 (95% CI: 0.86-0.98 p < 0.01) to 0.36 (95% CI: 0.18-0.73 p < 0.01). During the same time period, no similar reduction was found in young women 18-22 years. After introduction of HPV vaccine program, IRR for CIN2+ in young women 15-17 was significantly reduced for CIN2+ (0.14; 9...Continue Reading

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Citations

May 31, 2016·Journal of Oncology·Gregory Robertson, Stephen J Robson
Dec 10, 2016·The Indian Journal of Medical Research·Rengaswamy SankaranarayananPartha Basu
Apr 29, 2016·Technology in Cancer Research & Treatment·Mukesh Verma
Dec 6, 2017·Human Vaccines & Immunotherapeutics·Noelia LópezRuth Gil-Prieto
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Sep 1, 2018·Journal of Lower Genital Tract Disease·Anna-Barbara MoscickiJulia M L Brotherton
Aug 25, 2018·The Journal of Obstetrics and Gynaecology Research·Leon Foster, Stephen J Robson
Aug 10, 2020·Cancer·Emily V HeerMiranda M Fidler-Benaoudia
Feb 19, 2021·Journal of Pediatric and Adolescent Gynecology·Alla Vash-MargitaVanessa K Dalton
Mar 15, 2019·Acta Cytologica·Cristina Mendes de OliveiraLuisa Lina Villa
Nov 23, 2021·Human Vaccines & Immunotherapeutics·Kosuke HiramatsuKentaro Shimura

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