Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report.

Cases Journal
Ibrahim ElghissassiHassan Errihani

Abstract

HER-2 is overexpressed in 20 to 30% of breast cancer. Generally, metastases of a breast tumor have the same HER-2 status, although some discordances were reported.We report a case of reduction in HER-2 expression assessed by immunohistochemistry, following one day of a Trastuzumab injection, of a metastatic breast cancer to lymph nodes. Initially, the breast tumor HER-2 status was positive according to the same technique.We raise a hypothesis about technical interference and discuss the case in the framework of the existing literature.

References

Sep 1, 1995·Breast Cancer Research and Treatment·N QuénelJ M Coindre
Aug 2, 2001·Journal of the National Cancer Institute·R SimonG Sauter
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Oct 7, 2008·Japanese Journal of Clinical Oncology·Shigeya KyodaToshiaki Morikawa

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Citations

Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Meriem SlaouiMariam Amrani

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Methods Mentioned

BETA
biopsy

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