Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: assessment by MRI

Biological Psychiatry
H FukuzakoT Fujimoto

Abstract

We performed contiguous, 1 mm thick, magnetic resonance imaging scans in 18 men with chronic schizophrenia and in 18 age-matched healthy subjects to test in living patients the findings of a previous postmortem study. The schizophrenic patients showed bilaterally shortening (left, -6%; right, -9%) and volume reduction (left, -9%; right, -11%) of the hippocampal formation (HF). Volumes of HF correlated positively with HF length in the schizophrenic patients. The reduction in bilateral HF volumes was small after controlling for HF lengths (left, -3%; right, -3%). In schizophrenic patients, significant negative correlations were found bilaterally between the length of HFs and the scores for attention, bizarre behavior, and positive formal thought disorder. The results suggest that the volume reduction seen in the HFs of schizophrenic patients was caused mainly by a shortening of the HF and that these clinical symptoms may be associated with shorter HF length.

References

Jul 1, 1976·Archives of General Psychiatry·J M Davis
Jan 1, 1979·European Neurology·J JulienB Bourgoin
Jul 1, 1992·Biological Psychiatry·G CalabreseM W Weiner
Aug 1, 1992·Brain : a Journal of Neurology·M J CookJ M Stevens
Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P F LiddleR S Frackowiak
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Oct 1, 1991·Archives of General Psychiatry·B BogertsB Greve
Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T BeckerH Beckmann
Nov 1, 1990·The American Journal of Psychiatry·P E BartaL E Tune
Oct 15, 1987·The Journal of Comparative Neurology·R InsaustiW M Cowan
Mar 1, 1989·The Japanese Journal of Psychiatry and Neurology·R KanH Kumashiro
Nov 1, 1989·Archives of General Psychiatry·D V Jeste, J B Lohr
Jan 1, 1987·Neuropsychologia·S C SchachterN Geschwind
Oct 15, 1987·The Journal of Comparative Neurology·R InsaustiW M Cowan
Jan 1, 1986·European Archives of Psychiatry and Neurological Sciences·P Falkai, B Bogerts
Jan 1, 1985·Schizophrenia Bulletin·R M BilderA K Pandurangi
Aug 1, 1967·Archives of Neurology·N Malamud
Apr 1, 1994·Schizophrenia Research·A RossiM Casacchia
Apr 15, 1994·Biological Psychiatry·R B ZipurskyA Pfefferbaum
Aug 1, 1993·Schizophrenia Research·M Sarai, H Matsunaga
Feb 15, 1993·Biological Psychiatry·B BogertsS Masiar
Sep 1, 1962·The Journal of Mental Science·E A SERAFETINIDES, M A FALCONER

❮ Previous
Next ❯

Citations

Jan 1, 1997·European Archives of Psychiatry and Clinical Neuroscience·H FukuzakoM Takigawa
Nov 7, 2000·Biological Psychiatry·B S McEwen
Jul 2, 1999·Journal of Neuroscience Methods·F OhlE Fuchs
Mar 21, 2001·Neuroscience Letters·D C DaviesA C James
Aug 1, 1997·Journal of Chemical Neuroanatomy·L P Reagan, B S McEwen
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Nov 1, 2002·Schizophrenia Research·Lisa J PhillipsPatrick D McGorry
Feb 20, 2003·Schizophrenia Research·Mary P PeguesRaymond F Deicken
Aug 5, 1998·Schizophrenia Research·A B WhitworthW W Fleischhacker
Feb 16, 1999·Schizophrenia Research·I C WrightP K McGuire
Jul 14, 1999·Schizophrenia Research·R F DeickenD Amend
Jun 5, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·B S McEwenL P Reagan
Apr 26, 2003·Psychiatry Research·Lara L Davidson, R Walter Heinrichs
Jan 10, 2003·Psychiatry and Clinical Neurosciences·Masayoshi Kurachi
May 23, 2009·Schizophrenia Bulletin·Michael J ColemanDeborah L Levy
Jun 21, 1997·Annals of the New York Academy of Sciences·B S McEwen, A M Magarinos
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
May 20, 1999·Biological Psychiatry·R W McCarleyM E Shenton
Feb 28, 2008·Stress : the International Journal on the Biology of Stress·C D ConradR J Hobbs
May 3, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Fulvia AdrianoGianfranco Spalletta
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K RaziL E DeLisi
Mar 31, 1998·The British Journal of Psychiatry : the Journal of Mental Science·S M Lawrie, S S Abukmeil
Feb 17, 1998·The British Journal of Psychiatry : the Journal of Mental Science·D E Ross, D E Rous
Jun 7, 2019·The British Journal of Psychiatry : the Journal of Mental Science·Shu LiuBing Liu
Oct 31, 2002·Human Psychopharmacology·Bruce S. McEwen, Ana Maria Magarinos
May 10, 2002·Annals of the New York Academy of Sciences·B S McEwen
Sep 1, 2017·Neuroscience and Biobehavioral Reviews·Philip J SumnerSusan L Rossell
Nov 9, 2005·Brain Research. Molecular Brain Research·Goichiro TamuraTimothy G Clark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.