Reduction in magnetic resonance imaging T2 burden of disease in patients with relapsing-remitting multiple sclerosis: analysis of 48-week data from the EVIDENCE (EVidence of Interferon Dose-response: European North American Comparative Efficacy) study.

BMC Neurology
Anthony TraboulseeUBC MS/MRI Research Group

Abstract

The EVIDENCE (EVidence of Interferon Dose-response: European North American Comparative Efficacy) study was an international, randomized, open-label, assessor-blinded, parallel-group study assessing the efficacy and tolerability of interferon (IFN) beta-1a, 44 mcg subcutaneously (sc) three times weekly (tiw), and IFN beta-1a, 30 mcg intramuscularly (im) once weekly (qw), in patients with relapsing-remitting multiple sclerosis (RRMS). The aim of this analysis was to assess whether reductions in T2 burden of disease (BOD) were greater for patients receiving IFN beta-1a, 44 mcg sc tiw, than for those treated with IFN beta-1a, 30 mcg im qw, and to assess the impact of neutralizing antibodies (NAbs). A post-hoc analysis was performed on magnetic resonance imaging (MRI) data collected prospectively from the EVIDENCE study. The analysis included all patients with evaluable T2 MRI scans at the start of dosing and at week 48, and those who received at least one drug dose (n = 553). Lesions were identified by a radiologist blinded to treatment codes and the total volume of T2 lesions (BOD) was reported in mm3. Both median percentage decreases and absolute reduction in BOD were greater in the IFN beta-1a, 44 mcg sc tiw, treatment group. T...Continue Reading

References

Jun 27, 2001·Neurology·UNKNOWN PRISMS Study Group and the University of British Columbia MS/MRI Analysis Group.
Nov 27, 2002·Neurology·H PanitchUNKNOWN University of British Columbia MS/MRI Research Group
Mar 12, 2004·Journal of Neurology·Paola PeriniPaolo Gallo
Jul 13, 2005·Neurology·L KapposUNKNOWN European Interferon Beta-1a IM Dose-Comparison Study Investigators
Jul 13, 2005·Neurology·Gordon S FrancisUNKNOWN PRISMS Study Group

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Citations

Jul 16, 2010·Neuropsychiatric Disease and Treatment·David W Brandes
Mar 13, 2009·Expert Opinion on Biological Therapy·L DurelliUNKNOWN OPTIMS Trial NAb Sub-Study Group
Feb 25, 2009·Expert Opinion on Pharmacotherapy·Hans-Peter Hartung
Jul 6, 2010·IEEE Transactions on Bio-medical Engineering·Jon McAuslandDavid K B Li
May 23, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Xun Yang HuAlexander Rauscher

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