Reduction in neointimal formation with a stent coated with multiple layers of releasable heparin in porcine coronary arteries

Journal of Cardiovascular Pharmacology
Yasuharu MatsumotoAkira Takeshita

Abstract

Recent studies demonstrated that neointimal formation, which is caused by both neointimal proliferation and organized mural thrombus, is responsible for in-stent restenosis. Although various types of heparin coatings were effective in reducing (sub)acute thrombosis, most of them failed to reduce neointimal proliferation. This study was designed to examine the effect of the stent coated with multiple layers of releasable heparin complex from which heparin diffuses into the surrounding tissue and exerts its beneficial effects. Male Yorkshire pigs underwent balloon expandable stenting for coronary segments of both the left anterior and the left circumflex coronary arteries with a comparable diameter (n = 10). The stent implantation site was randomized for either control or heparin-coated stent. Four weeks after the procedure, quantitative coronary angiography (QCA) and intravascular ultrasonographic imaging (IVUS) were performed followed by histologic analysis. In additional animals, staining for proliferating cell nuclear antigen (PCNA) was performed 10 d after the procedure (n = 3). QCA demonstrated that coronary diameter (mm) was significantly larger at the heparin-coated stent site (2.32 +/- 0.14) compared with the control ste...Continue Reading

References

Feb 1, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
Dec 1, 1995·Journal of the American College of Cardiology·C UnterbergA B Buchwald
Jan 13, 1998·Journal of the American College of Cardiology·R KornowskiM B Leon
Sep 19, 1998·Journal of the American College of Cardiology·O F BertrandM G Bourassa
Oct 27, 1998·Circulation·E J Topol, P W Serruys
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M A Lovich, E R Edelman
Oct 19, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Y K AhnJ C Kang
Oct 12, 2000·JAMA : the Journal of the American Medical Association·A M Lincoff
Apr 17, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·K MorishigeA Takeshita

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Citations

Jun 18, 2009·Cardiovascular and Interventional Radiology·Frank AhlhelmWolfgang Reith
Dec 4, 2013·ACS Applied Materials & Interfaces·Liang-Cheng SuMei-Chin Chen
Oct 13, 2007·Biomacromolecules·Hironobu TakahashiDavid W Grainger
Dec 26, 2006·Biomaterials·Gopinath ManiC Mauli Agrawal
Sep 6, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Feroze NazneenMichael Thompson
Aug 5, 2009·Journal of Cellular Physiology·Hicham MrabatCharles A Hales
Apr 12, 2005·The Journal of Surgical Research·Torsten UeberrueckThorsten Wahlers
Aug 13, 2004·Atherosclerosis·Anita C Thomas, Julie H Campbell
Jan 4, 2006·Current Problems in Cardiology·Amar M SalamDavid R Holmes
Oct 7, 2004·Journal of the American College of Cardiology·Robert S SchwartzRenu Virmani
Jul 25, 2013·Atherosclerosis·Blandine MaurelStephan Haulon
Mar 12, 2003·Circulation·Michael HaudeUNKNOWN Heparin-COAted STents in small coronary arteries Trial Investigators
Nov 20, 2002·Circulation·Mohan N Babapulle, Mark J Eisenberg
Jun 13, 2017·Current Physical Medicine and Rehabilitation Reports·Tamara L Vos-Draper, Melissa M B Morrow
Aug 7, 2007·Biomacromolecules·Mei-Chin ChenHsing-Wen Sung
Jun 19, 2003·Journal of the American Chemical Society·Benjamin ThierryMaryam Tabrizian

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