Reduction in temporal lobe size in siblings with schizophrenia: a magnetic resonance imaging study

Psychiatry Research
I D DauphinaisE S Gershon

Abstract

Twenty-eight individuals with familial schizophrenia, from 16 unrelated families (12 sibling pairs and 4 individuals whose siblings refused scanning), and 21 normal control subjects were examined by cerebral magnetic resonance imaging (MRI). Measurements of the cerebrum, temporal lobes, and cerebral lateral ventricles were obtained using consecutive coronal sections containing these structures. Temporal lobe volume was significantly decreased by approximately 10% in these early onset schizophrenic siblings compared with normal controls. These findings add to recent post-mortem and neuroradiological evidence for morphological alteration in the temporal lobes in schizophrenia.

References

May 1, 1979·Archives of General Psychiatry·C Mazure, E S Gershon
Mar 22, 1990·The New England Journal of Medicine·R L SuddathD R Weinberger
Sep 1, 1989·Psychiatry Research·T J CrowD G Owens
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·E C JohnstoneN Colter
Feb 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·E C JohnstoneR E Steiner
Jun 1, 1988·Archives of General Psychiatry·J R KelsoeD R Weinberger
Jan 1, 1987·Psychiatry Research·R C SmithM Calderon
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Oct 1, 1987·Archives of General Psychiatry·L E DeLisiE S Gershon
Jan 1, 1986·Journal of Neural Transmission·H Jakob, H Beckmann
Feb 1, 1986·Archives of General Psychiatry·N AndreasenJ H Crossett
Feb 1, 1986·Archives of General Psychiatry·L E DeLisiE S Gershon
Nov 1, 1985·Acta Psychiatrica Scandinavica·R J MathewW H Wilson

❮ Previous
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Citations

Feb 15, 1993·Biological Psychiatry·B BogertsS Masiar
Dec 1, 1994·Biological Psychiatry·W G HonerP Falkai
Apr 15, 1994·Biological Psychiatry·R B ZipurskyA Pfefferbaum
Apr 1, 1994·Schizophrenia Research·A KleinschmidtH Steinmetz
Aug 1, 1995·Schizophrenia Research·D R Weinberger, B K Lipska
May 31, 1996·Psychiatry Research·J R DeQuardoR Tandon
Oct 7, 1996·Psychiatry Research·G BartzokisK Laack
Feb 13, 2001·Schizophrenia Research·J ZahajszkyM E Shenton
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Nov 1, 2002·Schizophrenia Research·Lisa J PhillipsPatrick D McGorry
May 27, 2003·Schizophrenia Research·Steven A ChanceTimothy J Crow
Dec 15, 1996·Schizophrenia Research·K E WardS C Schulz
Apr 26, 2003·Psychiatry Research·Lara L Davidson, R Walter Heinrichs
Dec 2, 2005·Schizophrenia Bulletin·Kang SimStephan Heckers
Jul 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·K McKennaJ L Rapoport
Feb 1, 1997·Psychiatry and Clinical Neurosciences·T OhnumaH Arai
Jan 1, 1995·Annual Review of Medicine·K J Kotrla, D R Weinberger
Sep 3, 1999·Biological Psychiatry·G D Pearlson, L Marsh
May 20, 1999·Biological Psychiatry·R W McCarleyM E Shenton
Oct 18, 2000·Biological Psychiatry·L F JarskogJ A Lieberman
May 4, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Koichi OharaHaruo Shibuya
Jul 12, 2002·Journal of Neuroscience Research·Ou BaiXin-Min Li
Apr 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Steven A ChanceTimothy J Crow
Apr 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·I SommerA Bouma
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K RaziL E DeLisi
Mar 31, 1998·The British Journal of Psychiatry : the Journal of Mental Science·S M Lawrie, S S Abukmeil
May 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·S E Chua, P J McKenna
Jan 3, 2001·Brain : a Journal of Neurology·N F MoranS D Shorvon

❮ Previous
Next ❯

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