Reduction in TIMP-2 serum levels predicts remission of inflammatory bowel diseases

European Journal of Clinical Investigation
Federico CarboneEdoardo G Giannini

Abstract

Growing evidence indicates tissue inhibitors of matrix metalloproteinases (TIMPs) as potential players in inflammatory bowel disease (IBD), but, no prospective data are available in IBD remission/relapse. In this prospective pilot study, a cohort of IBD patients (n = 32) was enrolled and treated with monoclonal anti-TNF-α antibodies. Patients were clinically followed up for a median period of 54 weeks. Serum circulating levels of C-reactive protein (CRP), TIMP-1 and -2, matrix metalloproteinase (MMP)-9 and -8, myeloperoxidase (MPO) and neutrophil elastase (NE) were assessed by ELISA at enrolment and at the end of the treatment. The percentage (%) TIMP-2 reduction from baseline to end of treatment was independently associated with IBD remission at the end of treatment and follow-up as well. ROC curve analysis further confirmed the good prognostic accuracy of % TIMP-2 reduction over the treatment period. Conversely, no other change in inflammatory molecule concentrations was able to predict short- or long-term IBD remission. This study indicates TIMP-2 reduction during IBD treatment with monoclonal anti-TNF-α antibodies as a potential prognostic parameter of short and long term remission. To understand if TIMP-2 is an innocent bi...Continue Reading

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Citations

Nov 21, 2018·European Journal of Clinical Investigation·Nicholas BardiFabrizio Montecucco
Apr 16, 2020·European Journal of Clinical Investigation·Giorgia BodiniEdoardo G Giannini
Jun 26, 2020·European Journal of Clinical Investigation·Aldo BonaventuraFabrizio Montecucco
May 12, 2020·Frontiers in Medicine·Peng ChenShenghong Zhang
Apr 4, 2021·International Journal of Molecular Sciences·Vincent MariauleMoez Rhimi

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