Reduction in urea distribution volume over time in clinically stable dialysis patients

Kidney International
Salvatore DI FilippoFrancesco Locatelli

Abstract

We have previously shown that, assuming urea distribution volume (V) remains constant for 1 month, ionic dialysance (ID) allows the dialysis dose to be calculated without the need for blood sampling. The aim of this multicenter study was to verify whether the assumption of a constant V can be extended to 1 year. In clinically stable patients receiving thrice-weekly hemodialysis at 13 dialysis centers, V and Kt/V were assessed during three dialysis sessions at baseline and 1 year later using ID as dialyzer urea clearance and the single-pool urea kinetic model. Baseline albumin, hemoglobin, and C reactive protein were prespecified covariates for predicting the change in V over time. Of the 52 enrolled patients, 40 (25 males; age 63.0+/-13.5 years) completed the study. Baseline end-dialysis body weight (62.4+/-13.7 kg) showed a non-significant 1% reduction during follow-up (-0.6+/-2.8 kg; P=0.175), whereas V significantly decreased from 29.0+/-6.8 to 27.4+/-6.0 l (-1.6+/-3.0 l or 4.5%; P=0.002). The reduction in V was greater when baseline albumin was lower (P=0.001) and baseline V was higher (P=0.005). The single-pool K(t)/V calculated using baseline V underestimated the actual value by 0.07+/-0.16 (P=0.008). The slight underesti...Continue Reading

References

Dec 1, 1988·Kidney International·L A PedriniS Rasmy
Sep 1, 1985·Kidney International·F A Gotch, J A Sargent
May 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R M HakimG Schulman
May 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T F ParkerE G Lowrie
Jul 1, 1995·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J T Daugirdas, D Schneditz
Jan 1, 1996·American Journal of Nephrology·T A Depner
Aug 1, 1996·Kidney International·P J HeldR M Hakim
Oct 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C ManzoniF Locatelli
Aug 1, 1997·Journal of the American Society of Nephrology : JASN·D W CoyneD W Windus
Jul 2, 1998·Kidney International·S Di FilippoF Locatelli
May 7, 1999·Kidney International·W D KloppenburgR M Huisman
Feb 14, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christopher W McIntyreRichard J Fluck
Jun 7, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Francis Dumler
Jul 16, 2004·Kidney International·Salvatore Di FilippoFrancesco Locatelli

❮ Previous
Next ❯

Citations

Aug 14, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elizabeth J LindleyEric J Will
Jun 24, 2010·Néphrologie & thérapeutique·Alain FicheuxAngel Argilés

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Kidney International
Salvatore DI FilippoFrancesco Locatelli
Néphrologie & thérapeutique
Afef KoubaaThierry Petitclerc
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Alain FicheuxAngel Argilés
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
E NoiriM Tsuchiya
© 2021 Meta ULC. All rights reserved