Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma

Cancer Science
Hiroshi TatsuwakiTetsuo Arakawa

Abstract

Prostaglandin (PG) E(2) promotes gastrointestinal carcinogenesis and tumor progression. We determined the correlations between pattern of expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a catabolic enzyme for biological inactivation of PGE(2), in gastric adenocarcinoma and various clinicopathological factors and patient outcome in an attempt to elucidate its biological significance. In 35 of 71 cases of gastric adenocarcinoma, expression of 15-PGDH protein was reduced in tumor tissues. Multivariate analysis revealed reduction of 15-PGDH expression to be an independent predictor of poor survival. The proportion of Ki67-positive cells in 15-PGDH-negative adenocarcinoma was higher than that in 15-PGDH-positive adenocarcinoma. No differences were found in clinicopathological parameters between patients with cyclooxygenase-2 (COX-2)-positive tumors and those with COX-2 negative tumors. In an in vitro study, use of specific siRNA to silence 15-PGDH or a specific inhibitor of 15-PGDH enhanced cell proliferation in the gastric cancer cell line AGS, which expresses 15-PGDH. These findings suggest that reduction of 15-PGDH is an independent predictor of poor survival associated with enhancement of cell proliferation in gas...Continue Reading

References

Sep 7, 1995·The New England Journal of Medicine·E GiovannucciF E Speizer
Dec 1, 1994·Cancer Metastasis Reviews·M J Thun
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·C M Ensor, H H Tai
Sep 1, 1996·British Journal of Cancer·W MüllerH E Gabbert
Jan 1, 1997·Advances in Pharmacology·W E Smalley, R N DuBois
Feb 18, 1999·The American Journal of Gastroenterology·H MurataM Hori
Oct 3, 1999·Physiological Reviews·S NarumiyaF Ushikubi
Feb 11, 2000·Annals of the New York Academy of Sciences·C WilliamsR N DuBois
Apr 4, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshiya FujimotoTadakazu Shimoda
Sep 6, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tetsuya TanigawaTetsuo Arakawa
Nov 18, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kirsi SaukkonenAri Ristimaki
Mar 31, 2004·Cancer Letters·Hideyuki IshidaHitoshi Kawakami
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hirokazu OkanoNobuhiko Tanigawa
Nov 16, 2004·The Journal of Biological Chemistry·Michael G BacklundRaymond N DuBois
May 19, 2005·Cancer Research·Dimitri LodyginHeiko Hermeking
Jul 5, 2005·Expert Opinion on Investigational Drugs·C S WilliamsR N DuBois
Aug 25, 2005·Gut·D Wang, R N Dubois
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seung-Jae MyungSanford D Markowitz
Aug 4, 2006·Cancer Research·Ido WolfH Phillip Koeffler
Dec 16, 2006·Digestive Diseases and Sciences·Tetsuya TanigawaAndrzej S Tarnawski
Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J M Fernández-CebriánM Ramos Fernández
Jan 5, 2008·Carcinogenesis·Zhenxiong LiuDaiming Fan
Dec 25, 2008·Yonsei Medical Journal·Tae Jung JangKi Hoon Jung
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexandra ThielAri Ristimäki

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Citations

Oct 18, 2011·Cancer Metastasis Reviews·Alexandra ThielAri Ristimäki
Oct 25, 2011·Cancer Metastasis Reviews·Hsin-Hsiung Tai
Aug 16, 2013·Journal of Lipid Research·Nathaniel W SnyderIan A Blair
Mar 15, 2012·World Journal of Gastroenterology : WJG·Li-Hong LouKai Wu
Feb 7, 2013·Journal of Cancer Research and Clinical Oncology·Binglan ZhangYuquan Wei
Aug 8, 2015·Journal of Gastroenterology and Hepatology·Shogo TakedaTetsuo Arakawa
Aug 26, 2011·Prostaglandins & Other Lipid Mediators·Emily R GreeneDipak Panigrahy
Dec 28, 2010·Experimental and Molecular Pathology·Hyunki KimHoguen Kim
Jun 21, 2014·Annals of Surgical Treatment and Research·Jae Hyun KangKwang Hee Kim
Apr 2, 2019·Scientific Reports·Nicholas J MonteleoneDan A Dixon
Sep 5, 2020·Cancer Management and Research·Yaling LiYongqi Liu
Nov 28, 2012·Journal of the Korean Society of Coloproctology·Pil Sung KangKyung Jong Kim
Nov 27, 2017·Metabolomics : Official Journal of the Metabolomic Society·Junjie ZhangChun Cai
Oct 22, 2020·International Journal of Molecular Sciences·Catarina LopesMário Dinis-Ribeiro
Apr 5, 2014·Molecular Cancer Research : MCR·Lu LuTong Wu

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