PMID: 9631959Jun 19, 1998Paper

Reduction of 3,4-diaminopyridine-induced biogenic amine synthesis and release in rat brain by gabapentin

Psychopharmacology
T A PugsleyDavid J Dooley

Abstract

The anticonvulsant drug gabapentin has been shown recently to exhibit anxiolytic and analgesic actions in animals. Such actions have been postulated in part to reflect effects on biogenic amine neuronal activity. Therefore the effects of gabapentin on biogenic amine neuronal activity were assessed by measuring the synthesis of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in rat brain and on the release of [3H] NE from rat hippocampal slices both in the presence and absence of the depolarizing agent 3,4-diaminopyridine (DAP). Gabapentin (30 and 100 mg/kg, i.p.) did not alter the basal synthesis rates of NE and DA as assessed by the unchanged accumulation of L-dihydroxyphenylalanine (DOPA) in the NE-enriched hippocampus and cortex and in the DA-enriched striatum and mesolimbic areas. Gabapentin also did not alter 5-HT synthesis as determined by the unaltered accumulation of 5-hydroxytryptophan (5-HTP) in the same brain areas. DAP (2 mg/kg, i.p.) induced a modest but significant increase in DOPA accumulation in the hippocampal, mesolimbic and striatal regions. This DAP-induced increase in DOPA accumulation was antagonized significantly in the hippocampus and mesolimbic regions by gabapentin at 30 and 100 mg/kg and in st...Continue Reading

Citations

Apr 3, 1999·Medicinal Research Reviews·J S Bryans, D J Wustrow
Aug 17, 2001·Brain Research. Developmental Brain Research·P SzotP A Schwartzkroin
Aug 4, 1999·Trends in Pharmacological Sciences·R M EglenA Dray
Aug 30, 2003·Behavioural Brain Research·Jennifer M Bossert, Keith B J Franklin
Apr 29, 1998·Epilepsy Research·C P TaylorL Singh
Sep 4, 2008·Brain : a Journal of Neurology·A LotheP Ryvlin
Apr 7, 2005·International Clinical Psychopharmacology·Gerald PfefferHoward C Margolese
Jun 3, 2009·Alcoholism, Clinical and Experimental Research·Hugh MyrickCarrie L Randall
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Hugh MyrickScott Henderson
Jul 22, 2008·Arquivos de neuro-psiquiatria·Cristiane Fiquene ContiGilmar Fernandes do Prado

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