Reduction of adhesion formation and promotion of wound healing after laminectomy by pharmacological inhibition of pro-inflammatory cytokines: an experimental study in the rat.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Kjell Olmarker

Abstract

In a previous experiment using TNF inhibition in the rat it was accidentally found that adhesion and scar formation was reduced compared to previous experience. Wound and bone healing also seemed enhanced. The present study was conducted to assess if this observation could be verified in a controlled setting using a standardized laminectomy in the rat. Five rats received doxycycline and five other rats received saline and served as control. Macroscopic blinded evaluation 1 week after the laminectomy revealed that adhesion and scar formation was less in doxycycline-treated animals than in control animals. Wound and bone healing was found to be better in doxycycline-treated animals. The mechanisms for the observed effects cannot be fully understood but the data indicate that further research may lead to opportunities to design pharmacological modalities to reduce adhesion and scar formation, maybe in combination with suitable barriers.

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Citations

Dec 14, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Chang Hun YuHwa Nam
Aug 15, 2014·Biomedical Journal·Jian-Ming ChenWen-Jer Chen
Jul 30, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Cheng-Yi WuI-Ming Jou
Nov 29, 2012·Osteoarthritis and Cartilage·H H LeeC R Chu
Jan 25, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Jean-Marie BerthelotYves Maugars
May 28, 2014·Acta Cirúrgica Brasileira·Ian Göedert Leite Duarte, Ivana Duval-Araujo
May 23, 2018·International Journal of Molecular Sciences·Kiyoshi KikuchiHisaaki Uchikado
Oct 4, 2020·World Neurosurgery·Cem DemirelCengiz Cokluk

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