Reduction of adhesion formation by intraperitoneal administration of a recombinant Hirudin analog

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
K E RodgersG S diZerega

Abstract

Adhesion formation is a major source of postoperative morbidity and mortality. Therefore, the reduction of postoperative adhesion formation would be of clinical benefit. Various modalities have been shown to reduce adhesion formation, including fibrinolytic enzymes, nonsteroidal anti-inflammatory drugs, and barriers that reduce the apposition of sites of potential adhesion formation. This study examined the ability of an inhibitor of thrombin, a recombinant hirudin analog (recHirudin), to reduce the formation of intraperitoneal adhesions in two rabbit models of adhesion formation. In the sidewall and double uterine horn models, recHirudin was administered via Alzet miniosmotic pump for the entire postoperative interval. In both of these models, there was a dose-dependent reduction in adhesion formation as measured by (1) the area of the sidewall injury that was involved in adhesions to the cecum and the bowel or (2) the involvement of the uterine horns to themselves or other peritoneal organs. These studies clearly demonstrate that postoperative administration of recHirudin to the site of injury reduced the formation of postoperative adhesions in two animal models.

References

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Citations

Apr 15, 2006·Digestive Diseases and Sciences·Axel SchneiderUdo Rolle
Jan 5, 2012·Human Reproduction·Mehmet Serdar KutukAhmet Ozturk
Apr 13, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Remah M Kamel
Dec 29, 2009·The Journal of Surgical Research·Brian C Ward, Alyssa Panitch
Jul 21, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Christine WeisDorothee Freytag
Nov 16, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Christine Weis, Erich K Odermatt
Oct 8, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bernd Martin JaenigenRobert Obermaier
Nov 25, 1998·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·K E RodgersG S diZerega
Jul 12, 2020·Materials·Heekyung ParkDonghyun Lee
Sep 2, 2020·Acta Biomaterialia·Jingyi TangShengfu Chen

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