Reduction of allergic airway eosinophilia by dietary raffinose in Brown Norway rats

The British Journal of Nutrition
Hiroshi WatanabeTakanori Kasai

Abstract

Oral administration of raffinose, a naturally occurring indigestible oligosaccharide, has reportedly ameliorated atopic dermatitis in human subjects although the mechanism is unknown. The present study investigated the effect of dietary raffinose on allergen-induced airway eosinophilia in ovalbumin-sensitised Brown Norway rats as an atopic disease model. Brown Norway rats were immunised by subcutaneous injection with ovalbumin on day 0 and fed either a control diet or the diet supplemented with raffinose (50 g/kg diet). The rats were exposed to aerosolised ovalbumin on day 20, and broncho-alveolar lavage fluid was obtained on the next day. The number of eosinophils in the fluid was significantly lower in the rats fed the raffinose diet than in those fed the control diet. Dietary raffinose significantly reduced IL-4 and IL-5 mRNA levels in lung tissue and tended to lower ovalbumin-specific Ig E levels. Suppression of eosinophilia by dietary raffinose was still observed in caecectomised and neomycin-administered rats, suggesting little contribution by the colonic bacteria to the effect of raffinose. Intraperitoneal administration of raffinose also suppressed eosinophilia. Significant concentrations of raffinose were detected in p...Continue Reading

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Citations

Sep 24, 2009·The British Journal of Nutrition·Kei SonoyamaTetsuji Yanagihara
Jul 8, 2008·Bioscience, Biotechnology, and Biochemistry·Sooksan PirapatditKei Sonoyama
Nov 8, 2007·Bioscience, Biotechnology, and Biochemistry·Kyoko TomitaSatoshi Hachimura
Oct 13, 2009·The Journal of Allergy and Clinical Immunology·Jeroen HolEdward E Nieuwenhuis
Oct 24, 2007·The Journal of Nutrition·Stephanie Seifert, Bernhard Watzl
Dec 1, 2005·The Journal of Nutrition·Hiroyuki MizubuchiYasunobu Yoshikai
Jul 5, 2013·The American Journal of Clinical Nutrition·Prescilla V JeurinkLéon M J Knippels

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