PMID: 2110843Jan 22, 1990Paper

Reduction of arginine vasopressin binding sites in mouse lateral septum by treatment with 6-hydroxydopamine

Brain Research
H IshizawaP L Hoffman

Abstract

The neuropeptide arginine vasopressin modulates neuroadaptive processes, including memory consolidation and functional tolerance to ethanol, by actions at CNS V1 receptors. Noradrenergic systems play a role in these actions of the peptide. To assess whether vasopressin may act presynaptically on catecholamine neurons, vasopressin receptors were measured by quantitative autoradiography in the lateral septum, an area that is innervated by catecholaminergic neurons and has a high density of V1 receptors, of control and 6-hydroxydopamine-treated mice. Vasopressin receptors were distributed non-uniformly throughout the lateral septum, with greater binding in the more caudal regions. Treatment with 6-hydroxydopamine lowered septal catecholamine levels and vasopressin binding, with a greater effect on binding in the intermediate and caudal portions of the lateral septum. Pretreatment with desmethylimipramine reversed the depletion of norepinephrine, and attenuated the effect of 6-hydroxydopamine on vasopressin binding in the intermediate region, but was less effective in the caudal region of the lateral septum. The results suggest that a portion of septal vasopressin receptors are localized on the terminals of noradrenergic and, possi...Continue Reading

References

Jul 10, 1978·Cell and Tissue Research·O Lindvall, U Stenevi
Dec 7, 1978·Nature·P L HoffmanB Tabakoff
Mar 26, 1985·European Journal of Pharmacology·E R De KloetM Terlou
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M KiralyJ J Dreifuss
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·C L Melchior, B Tabakoff
Nov 27, 1984·European Journal of Pharmacology·C R HungP L Hoffman
Dec 1, 1982·Experimental Neurology·J E Marchand, N Hagino

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Citations

Nov 11, 2009·Bulletin of Experimental Biology and Medicine·P A KimA A Kamensky
Aug 15, 1995·European Journal of Pharmacology·P H WuH Kalant
Feb 1, 1990·Brain Research. Molecular Brain Research·P R GiriP L Hoffman
Apr 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G J BoerP Te Riele
Oct 1, 1998·European Journal of Pharmacology·J ChiuD A Lê
Oct 31, 1994·Annals of the New York Academy of Sciences·P L Hoffman
Jan 1, 1990·Annals of Medicine·P L HoffmanB Tabakoff
Jun 29, 2004·Pharmacology, Biochemistry, and Behavior·Tomoaki SatoTakashige Nishikawa
Jun 8, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Remco BredewoldAlexa H Veenema

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