Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Afton K LimbergMatthew P Abdel

Abstract

The dense formation of abnormal scar tissue after total knee arthroplasty results in arthrofibrosis, an unfortunate sequela of inflammation. The purpose of this study was to use a validated rabbit model to assess the effects on surgically-induced knee joint contractures of two combined pharmacological interventions: celecoxib (CXB) loaded on an implanted collagen membrane, and subcutaneously (SQ) injected ketotifen. Thirty rabbits were randomly divided into five groups. The first group received no intervention after the index surgery. The remaining four groups underwent intra-articular implantation of collagen membranes loaded with or without CXB at the time of the index surgery; two of which were also treated with SQ ketotifen. Biomechanical joint contracture data were collected at 8, 10, 16, and 24 weeks. At the time of necropsy (24 weeks), posterior capsule tissue was collected for messenger RNA and histopathologic analyses. At 24 weeks, there was a statistically significant increase in passive extension among rabbits in all groups treated with CXB and/or ketotifen compared to those in the contracture control group. There was a statistically significant decrease in COL3A1, COL6A1, and ACTA2 gene expression in the treatment g...Continue Reading

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Citations

Apr 3, 2021·Trends in Pharmacological Sciences·William A BlessingMark W Grinstaff
Apr 20, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Aaron R OwenMatthew P Abdel
Oct 29, 2021·Journal of Experimental Orthopaedics·Joaquin Sanchez-Sotelo

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