Reduction of B cell turnover in chronic lymphocytic leukaemia.

British Journal of Haematology
Julien DefoicheLuc Willems

Abstract

Whether chronic lymphocytic leukaemia (CLL) is a latent or a proliferating disease has been intensively debated. Whilst the dogma that CLL results from accumulation of dormant lymphocytes is supported by the unresponsiveness of leukaemic cells to antigens and polyclonal activators, recent in vivo kinetic measurements indicate that B lymphocytes do divide at significant rates in CLL. However, an important and still unanswered question is whether CLL cells proliferate faster or slower compared with their normal counterparts. This report addressed directly this point and compared B-cell kinetics in CLL subjects and healthy controls, using a pulse-chase approach based on incorporation of deuterium from 6,6-(2)H(2)-glucose into DNA. We confirmed that B cells proliferated at significant levels in CLL but found that the proliferation rates were reduced compared with healthy subjects (mean 0.47 vs. 1.31%/d respectively, P = 0.007), equivalent to an extended doubling time of circulating B cells (147 d vs. 53 d). In conclusion, CLL B cells proliferate at reduced levels compared with healthy controls. CLL is thus characterized by an aberrant B-cell kinetics with a decrease in cell turnover, an observation that may impact on elaboration of...Continue Reading

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Citations

Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rodney P KincaidChristopher S Sullivan
Nov 28, 2015·Viruses·Pierre-Yves BarezLuc Willems
Jul 14, 2010·Best Practice & Research. Clinical Haematology·Rajendra N DamleNicholas Chiorazzi
May 4, 2010·Leukemia Research·Derek C MacallanLuc Willems
Mar 17, 2009·Trends in Immunology·Becca AsquithDerek C Macallan
Apr 23, 2013·Clinical and Experimental Immunology·J B BollykyC J Greenbaum
Jun 21, 2012·British Journal of Haematology·Bastian Scholz, Rolf Marschalek
Aug 26, 2010·British Journal of Haematology·Julien DefoicheDerek C Macallan
Oct 15, 2011·Blood·Stéphane OlindoLuc Willems
Aug 22, 2009·Clinical Chemistry·Julien DefoicheDerek C Macallan
May 11, 2017·Frontiers in Immunology·Julio Lahoz-BeneytezBecca Asquith
Dec 11, 2019·Antibodies·Veena A Thomas, Joseph P Balthasar
Apr 2, 2020·Cold Spring Harbor Perspectives in Medicine·Nicholas ChiorazziKanti R Rai
Nov 3, 2020·Frontiers in Oncology·Marco V HaselagerEric Eldering
May 28, 2021·Frontiers in Oncology·Pablo OppezzoNicholas Chiorazzi

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