Reduction of blood platelet monoamine oxidase activity in schizophrenic patients on phenothiazines

Folia Psychiatrica Et Neurologica Japonica
S TakahashiN Tani

Abstract

A newly developed assay for monoamine oxidase (MAO) activity in blood platelets (serotonin used as substrate) was applied for the measurement of the enzyme activity in 76 schizophrenic patients. No significant reduction was found in the blood platelet MAO activity in a group of 33 untreated schizophrenic patients, as compared to that in the normal controls. Male patients revealed to have lower enzyme activity than females in the schizophrenic group, as we described previously in the normal subjects. Treatment with phenothiazines caused significant reduction of blood platelet MAO activity, while platelet serotonin content and platelet count appeared to be not affected by the drug treatment. The authors suggest that blood platelet MAO activity may be related to hormonal factors but not to psychiatric diagnosis of schizophrenia or constitution liable to schizophrenic illnesses.

References

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Citations

Aug 1, 1982·Psychiatry Research·M DuncavageH Y Meltzer
Feb 1, 1987·Psychiatry Research·R YehudaJ S Meyer
Sep 1, 1992·Schizophrenia Research·M A Marcolin, J M Davis
Mar 1, 1981·Journal of Clinical Pathology·M SandlerV Glover
May 1, 1988·Biological Psychiatry·G N PandeyJ M Davis
Jan 1, 1976·Folia Psychiatrica Et Neurologica Japonica·S TakahashiH Yamane
Jul 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·F OwenE C Johnstone
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·J Mann, K M Thomas
Mar 1, 1983·Acta Psychiatrica Scandinavica·P H YuA A Boulton
Oct 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·F OwenM Poulter
Jan 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·Z L KrukD F Scott
Jan 12, 1978·The New England Journal of Medicine·S G PotkinR J Wyatt

Related Concepts

Blood Platelets
Monoamine Oxidase
Phenothiazines
Schizophrenia
Hydroxytryptamine
Antipsychotic Effect

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